Honoring Tim

Tim Packhem touched—and saved—a lot of lives. It’s an impressive thing to say about anyone, but the fact that Tim could affect so many, in so short a time, is what makes him truly special. Those close to him affectionately knew him as “Tim-bo”—a friendly goofball who was quick with a joke or a hug. The kind of guy who walks up to you on your first day at a new school and invites you join him and his friends at the lunch table. At 16 years old, when Tim died from severe brain trauma after falling off a skateboard, the number of people who appreciated his carefree attitude became heartbreakingly clear. Almost his entire school came out to honor his memory at the wake. The line, stretching long and silent, snaked slowly past his casket with hundreds of people wanting to tell him goodbye, thank you, or both. Many of those who came to offer their condolences were unfamiliar to the family, but one thing the family immediately recognized was the impact Tim had made on so many lives. “I never hung out with him much, but I always thought Tim was one of the greatest guys in school.” “He was the funniest kid in class. Probably the only reason I ever looked forward to going to algebra.” “Tim was the best.” Just one month earlier, Tim had been studying for his learner’s permit. His Registry of Motor Vehicle instruction booklet taught him about organ donation, and at the dinner table one evening Tim told his mo...
Source: Thrive, Children's Hospital Boston - Category: Pediatrics Authors: Tags: All posts Donate life how organ donation saves lives National Donate Life Month Pediatric Transplant Center (PTC) Source Type: news

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AbstractSummaryPatients with cystic fibrosis awaiting lung transplantation for end-stage respiratory failure have high prevalence of reduced bone mineral density and fragility fracture. Suboptimal 25-hydroxyvitamin D levels could significantly contribute to the development of cystic fibrosis-related bone disease.IntroductionThe assessment of the prevalence of cystic fibrosis-related bone disease (CFBD) and its associated risk factors in young adults with cystic fibrosis (CF) awaiting lung transplantation for end-stage respiratory failure.MethodsClinical characteristics, bone mineral density (BMD), the parameters of calcium...
Source: Osteoporosis International - Category: Orthopaedics Source Type: research
ács A, Czebe K, Csiszér E, Mihály S, Kovács L, Müller V, Elek J, Rényi-Vámos F, Lang G Abstract The first lung transplantation in Hungary was performed on 12th of December, 2015. It was a joint effort of the National Institute of Oncology and the Semmelweis University. Hereby we summarise the results and experiences from the first three years. Until August, 2018, 55 lung transplantations were performed in Hungary. This was a retrospective analysis. All patients were listed according to the recommendation of the Lung Transplantation Committee. All implanted lungs have ...
Source: Orvosi Hetilap - Category: General Medicine Authors: Tags: Orv Hetil Source Type: research
Playing youth hockey and Little League in the spring of 1988, I started to become easily fatigued. I became very weak and could no longer run around. By May, a visit to my pediatrician resulted in a trip to the Boston Children’s Hospital Cardiology Clinic on Fegan 6 and the first of many cardiac catheterizations I would receive in my life. The results of that first procedure were shared in my corner room across from the nurses’ station on 6 East (the cardiac step-down at the time): I would need a heart transplant for cardiomyopathy. It was Friday the 13th. I was 10 years old. Tim, before he ...
Source: Thrive, Children's Hospital Boston - Category: Pediatrics Authors: Tags: Our Patients’ Stories cardiac catheterization cardiomyopathy heart transplant Heart transplant program kidney transplant Pediatric Transplant Center (PTC) Source Type: news
Conclusion: We strongly recommend the long term cardiovascular follow up on lung transplanted patient, because of the common systemic atherogen effect of the frequent infection and immunsupressive therapy.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Transplantation Source Type: research
We report the successful use of ceftolozane/tazobactam (C/T) to treat a pulmonary exacerbation in a 35 year old female, post lung transplant, with cystic fibrosis (CF), malnutrition, chronic kidney disease, and multi-drug resistant Pseudomonas aeruginosa infection (MDR PSA). Given the complexity of the clinical profile, we measured drug levels of C/T during treatment of her current exacerbation to determine pharmacokinetics. The patient achieved an estimated ceftolozane peak of 174.1 μg/mL and trough of 9.2 μg/mL. Serum half-life was found to be slightly shorter than previously reported in normal subjects, (2.3 hr. v...
Source: Respiratory Care - Category: Respiratory Medicine Authors: Tags: Respir Med Case Rep Source Type: research
We report the case of a 12-year-old girl with respiratory failure due to CF who underwent lung transplantation. She had been diagnosed with CF 8 years previously after being treated for recurrent Pseudomonas aeruginosa pneumonia and malnutrition based on sweat chloride concentrations and the CFTR protein gene mutation test. Progression to end-stage lung disease and respiratory failure led to registration with the Korean Network for Organ Sharing. She underwent successful double lung transplantation in 2014. Although she has diabetes mellitus and chronic kidney disease, she has a better quality of life and a prolonged life ...
Source: Journal of Korean Medical Science - Category: Biomedical Science Tags: J Korean Med Sci Source Type: research
We report the successful use of ceftolozane/tazobactam (C/T) to treat a pulmonary exacerbation in a 35 year old female with cystic fibrosis (CF), malnutrition, chronic kidney disease, post lung transplant and multi-drug resistant Pseudomonas aeruginosa infection (MDR PSA). Given the complexity of the clinical profile, we measured drug levels of C/T during treatment of her current exacerbation to determine pharmacokinetics. The patient achieved an estimated ceftolozane peak of 174.1 μg/mL and trough of 9.2 μg/mL. Serum half-life was found to be slightly shorter than previously reported in normal subjects, (2.3 hr. vs....
Source: Respiratory Medicine Case Reports - Category: Respiratory Medicine Source Type: research
ConclusionsAfter lung transplantation, AKI is common and often evolves into severe CKD, which is a known cause of morbidity and mortality. Supra-therapeutic whole-blood tacrolimus trough concentrations are related to the early onset of AKI. Conscientious targeting tacrolimus blood concentrations might be vital in the early phase after lung transplantation.What is known about this subject?• Lung transplant recipients often develop acute kidney injury evolving into chronic kidney disease increasing both morbidity and mortality.• To date, the pathophysiology of kidney injury after lung transplantation has not been f...
Source: European Journal of Clinical Pharmacology - Category: Drugs & Pharmacology Source Type: research
CONCLUSIONS: This study shows adequate predictive ability of CKD-EPI creatinine in the cohort as a whole, but unacceptable performance in patients with cystic fibrosis, low arm muscle area and/or low body mass index. Our findings demonstrate that cystatin C may be a preferable filtration marker in these subgroups. PMID: 28108166 [PubMed - as supplied by publisher]
Source: Clinical Biochemistry - Category: Biochemistry Authors: Tags: Clin Biochem Source Type: research
Conclusion: DM might have an impact on survival after lung transplantation. An organized and cooperative management of pre&post DM and NODAT seems warranted.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: 8.2 Transplantation Source Type: research
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