Calmodulin/CaMKII inhibition improves intercellular communication and impulse propagation in the heart and is antiarrhythmic under conditions when fibrosis is absent

Conclusion Both acute and chronic CaM/CaMKII inhibition improves conduction characteristics and enhances localization of Cx43 in the intercalated disc. In the absence of fibrosis, this reduced the susceptibility for arrhythmias.

Source: Cardiovascular Research - August 23, 2016 Category: Cardiology Authors: Takanari, H., Bourgonje, V. J. A., Fontes, M. S. C., Raaijmakers, A. J. A., Driessen, H., Jansen, J. A., van der Nagel, R., Kok, B., van Stuijvenberg, L., Boulaksil, M., Takemoto, Y., Yamazaki, M., Tsuji, Y., Honjo, H., Kamiya, K., Kodama, I., Anderson, M Tags: Ion Channels and Arrhythmias Source Type: research