The endothelial adrenomedullin-RAMP2 system regulates vascular integrity and suppresses tumour metastasis

Conclusion These findings indicate that the AM-RAMP2 system regulates vascular integrity, whereas RAMP2 deletion promotes vascular permeability and EndMT-like change within primary lesions and formation of pre-metastatic niches in distant organs by destabilizing the vascular structure and inducing inflammation. Vascular integrity regulated by the AM-RAMP2 system could thus be a hopeful therapeutic target for suppressing tumour metastasis.

Source: Cardiovascular Research - August 23, 2016 Category: Cardiology Authors: Tanaka, M., Koyama, T., Sakurai, T., Kamiyoshi, A., Ichikawa-Shindo, Y., Kawate, H., Liu, T., Xian, X., Imai, A., Zhai, L., Hirabayashi, K., Owa, S., Yamauchi, A., Igarashi, K., Taniguchi, S., Shindo, T. Tags: Vascular Biology Source Type: research