Knee replacement: Life changing or a disappointment?

While there are more than 100 types of arthritis, osteoarthritis is by far the most common. It’s the age-related, “wear-and-tear” type of arthritis that affects almost everyone fortunate enough to live a long life, affecting up to 80% of older adults. Fortunately, symptoms may be mild. But for those in whom symptoms are severe, treatment can make a big difference. So what can be done for osteoarthritis? The available treatments for osteoarthritis include: Non-medication approaches, such as physical therapy, loss of excess weight, or use of braces or a cane Complementary and alternative treatments, such as acupuncture, massage, or tai chi Medications, such as pain relievers, anti-inflammatory medications, or cortisone injections Surgery, such as knee or hip replacement. Surgery is usually a last resort. But for severe osteoarthritis, it’s often the only option likely to make much difference. In the United States alone, more than 600,000 knee replacements and 300,000 hip replacements are performed each year; and predictions are that these numbers will rise dramatically in the coming decades. And just how good is joint-replacement surgery? Most articles about joint replacement surgery (and the surgeons who perform them) make statements such as: “The vast majority of patients who have their knees replaced are markedly improved” or “More than 80% of people who have their hip replaced are glad they had it done.” While these statemen...
Source: New Harvard Health Information - Category: Consumer Health News Authors: Tags: Arthritis Health Healthy Aging Managing your health care Osteoarthritis Pain Management Surgery Source Type: news

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AbstractPurposeThe management of knee pain secondary to meniscal tears with osteoarthritis is limited by the poor inherent healing potential of the meniscus. Previous studies have reported on the benefit of autologous micro-fragmented fat as a therapeutic for various knee pathologies. The goal of this prospective pilot study was to determine the safety and potential treatment effect of micro-fragmented adipose tissue injection for patients with knee pain secondary to osteoarthritis and meniscal tears who have failed conservative management.MethodsTwenty subjects with knee pain secondary to osteoarthritis with associated me...
Source: International Orthopaedics - Category: Orthopaedics Source Type: research
CONCLUSION: OUD-hospitalizations increased in all 5 musculoskeletal diseases studied, but the rate of increase differed. Awareness of these OUD-hospitalization trends in 5 musculoskeletal diseases among providers, policy-makers and patients is important. Development and implementation of interventions, policies and practices to potentially reduce OUD-associated impact in people with rheumatic diseases is needed. PMID: 33004531 [PubMed - as supplied by publisher]
Source: Journal of Rheumatology - Category: Rheumatology Tags: J Rheumatol Source Type: research
This study was undertaken to determine whether treatment with ticagrelor was associated with a lower risk of OA.MethodsWe conducted a 1:2 propensity score –matching analysis using data from 2011–2017 in the Optum Clinformatics Data Mart. Patients who had received either ticagrelor or clopidogrel for ≥90 days were included in our study, and patients with a prior diagnosis of OA or inflammatory arthritis were excluded. OA was identified using Inte rnational Classification of Diseases codes. The primary outcome was the time to diagnosis of OA after treatment with ticagrelor versus clopidogrel.ResultsOur propens...
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Tags: Full Length Source Type: research
A study highlights the potential of fasinumab, an anti-nerve growth factor monoclonal antibody, as a pain treatment for osteoarthritis (OA) patients. Research into the risks and benefits of this therapeutic class for OA are ongoing...
Source: The Rheumatologist - Category: Rheumatology Authors: Tags: Drug Updates Osteoarthritis Arthritis & Rheumatology fasinumab Knee Osteoarthritis (OA) Nerve growth factor (NGF) tanezumab Source Type: research
This study aims to investigate the efficacy and mechanism of action of TG-C in a rat model of OA. Using the monosodium-iodoacetate (MIA) model of OA, we examined whether TG-C could improve OA symptoms and cartilage structure in rats. Our results showed that TG-C provided pain relief a nd cartilage structural improvement in the MIA OA model over 56 days. In parallel with these long-term effects, cytokine profiles obtained on day 4 revealed increased expression of interleukin-10 (IL-10), an anti-inflammatory cytokine, in the synovial lavage fluid. Moreover, the increased levels of TGF-β1 and IL-10 caused by TG-C in...
Source: Inflammopharmacology - Category: Drugs & Pharmacology Source Type: research
AbstractThere is a high percentage of error in the approach of patients with joint pain by primary care physicians. An algorithm can help improve this misdiagnosis problem. Our study seeks to determine the effectiveness of an algorithm when used by primary care physicians for the diagnosis of cases of joint pain patients. A randomized clinical experiment was carried out. Primary care physicians from five cities in Colombia developed a series of clinical cases, which were presented to them through a website on their personal cell phones. Half of the doctors developed the cases using the diagnostic algorithm, and the other h...
Source: Rheumatology International - Category: Rheumatology Source Type: research
We examined 16 review articles and 11 randomized controlled trials published in the last 5  years on the clinical efficacy of acupuncture in adults with CMP conditions. The available evidence suggests that acupuncture does have short-term pain relief benefits for patients with symptomatic knee osteoarthritis and chronic low back pain and is a safe and reasonable referral option. Acupunct ure may also have a beneficial role for fibromyalgia. However, the available evidence does not support the use of acupuncture for treating hip osteoarthritis and rheumatoid arthritis.SummaryThe majority of studies concluded the superi...
Source: Current Rheumatology Reports - Category: Rheumatology Source Type: research
A curcumin extract eased pain, stiffness and physical function in those with osteoarthritis of the knee.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Knees Turmeric (Spice) Placebos Arthritis Osteoarthritis Joints (Body Part) Source Type: news
This study aims to examine the effect of methotrexate (MTX) on knee effusion-synovitis and pain in symptomatic patients with mid- to late-stage KOA.Methods/designThis protocol describes a multicentre randomised placebo-controlled clinical trial aiming to recruit 200 participants with mid- to late-stage symptomatic KOA and with effusion-synovitis grade of ≥ 2. Participants will be randomly allocated to the MTX group (start from 5 mg per week for the first 2 weeks and increase to 10 mg per week for the second 2 weeks and 15 mg per week for the remaining period if tolerated) or the pla...
Source: Trials - Category: Research Source Type: clinical trials
Authors: Lacorda JB, Jung HG, Im JM Abstract The supramalleolar osteotomy is a joint-preserving surgical procedure. It is a very good treatment option for the asymmetric varus ankle and medial compartment osteoarthritis. The primary objective of the procedure is to shift medial concentration of stress toward the lateral intact articular cartilage to redistribute the joint loads during ambulation. Several studies have shown that deformities of the ankle result in uneven load distribution in the ankle joint, which eventually leads to articular cartilage degeneration. Since the lateral articular cartilage is intact, j...
Source: Clinics in Orthopedic Surgery - Category: Orthopaedics Tags: Clin Orthop Surg Source Type: research
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