Amyloid Precursor Protein Processing and Bioenergetics.

Amyloid Precursor Protein Processing and Bioenergetics. Brain Res Bull. 2016 Aug 18; Authors: Wilkins HM, Swerdlow RH Abstract The processing of amyloid precursor protein (APP) to amyloid beta (Aβ) is of great interest to the Alzheimer's disease (AD) field. Decades of research define how APP is altered to form Aβ, and how Aβ generates oligomers, protofibrils, and fibrils. Numerous signaling pathways and changes in cell physiology are known to influence APP processing. Existing data additionally indicate a relationship exists between mitochondria, bioenergetics, and APP processing. Here, we review data that address whether mitochondrial function and bioenergetics modify APP processing and Aβ production. PMID: 27545490 [PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/27545490?dopt=Abstract

Source: Brain Research Bulletin - August 17, 2016 Category: Neurology Authors: Wilkins HM, Swerdlow RH Tags: Brain Res Bull Source Type: research