Combined HRT breast cancer risk 'may have been underestimated'

Conclusion This study shows a link between the use of combined oestrogen and progesterone HRT and breast cancer risk, particularly among women who take the pill for a long period of time. But this is not the entire story. The study included a large cohort of women. The risk increase for combined HRT is based on only 52 of the 39,183 women taking the combined pill who developed breast cancer. Of these, only seven women had been taking the pill for more than 15 years. Therefore, the analysis was based on a very small number, which may mean the risk associations are not completely accurate. Assessments were based on self-report questionnaires, so there is a possibility of recall bias. For example, some information about use of HRT pills was collected from women after their breast cancer diagnosis. As the combined HRT pill has been linked to breast cancer, women may have recalled their use differently from those who didn't develop cancer. Although the researchers took into account a wide range of factors, it's possible that some unaccounted factors influenced the link. One of these factors the authors note is BMI, which should be taken into consideration, particularly when comparing results between studies. These findings will be of concern to women taking combination HRT. But there are a few extra points to put this into perspective. The baseline risk of developing breast cancer with combined HRT is still quite small...
Source: NHS News Feed - Category: Consumer Health News Tags: Cancer Medication Older people Source Type: news

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Publication date: Available online 15 January 2019Source: European UrologyAuthor(s): On behalf of EMA
Source: European Urology - Category: Urology & Nephrology Source Type: research
Conclusions: These data imply that a decrease in SPARC expression is correlated with dedifferentiation of BTC cells resulting in enhanced EMT being possibly mediated by TGF- β. Thereby SPARC levels might be a marker for individual prognosis of a patient, and strategies aiming at inhibition of SPARC downregulation might have potential for new future therapies.Eur Surg Res 2019;60:1 –12
Source: European Surgical Research - Category: Surgery Source Type: research
Purpose To assess the quality of the relationship between V˙O2peak estimated from patient outcomes on the 6-min walk test (6MWT) and the V˙O2peak calculated from patient outcomes on the University of Northern Colorado Cancer Rehabilitation Institute (UNCCRI) treadmill protocol. Methods Cancer survivors (N = 187) completed the UNCCRI treadmill protocol and a 6MWT 1 wk apart in randomized order to obtain V˙O2peak. Values from the UNCCRI treadmill protocol were compared against four common 6MWT V˙O2peak prediction equations. Results All four 6MWT prediction equations significantly (P
Source: Medicine and Science in Sports and Exercise - Category: Sports Medicine Tags: CLINICAL SCIENCES Source Type: research
Purpose Bariatric surgery is considered as an effective therapeutic strategy for weight loss in severe obesity. Remission of type 2 diabetes is often achieved after the surgery. We investigated whether increase in self-reported habitual physical activity associates with improved skeletal muscle insulin sensitivity and reduction of fat depots after bariatric surgery. Methods We assessed self-reported habitual physical activity using Baecke questionnaire in 18 diabetic and 28 nondiabetic patients with morbid obesity (median age, 46 yr; body mass index, 42.0 kg·m−2) before and 6 months after bariatric surger...
Source: Medicine and Science in Sports and Exercise - Category: Sports Medicine Tags: CLINICAL SCIENCES Source Type: research
Conclusions Substantial variability in response to standardized exercise was observed for change in both WC and body weight after accounting for the variability not attributed to exercise. Potential determinants of the interindividual variability in response to exercise remain unclear.
Source: Medicine and Science in Sports and Exercise - Category: Sports Medicine Tags: APPLIED SCIENCES Source Type: research
By 2030, there will be 9 million adults over age 65 in California — up from 6 million now — according to an estimate by the state’s department of finance. Buta new study by the UCLA Center for Health Policy Research finds that California ’s public mental health workforce is poorly prepared to address their mental health needs and provide treatment for substance abuse.The report ’s publication coincides with a meeting this week in San Diego of the California Behavioral Planning Council, which will discuss the workforce problem and a five-year workforce education and training plan. But...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
Digital breast tomosynthesis (DBT) finds 13% more invasive and early-stage...Read more on AuntMinnie.comRelated Reading: Are better clinical results from DBT worth the cost? DBT betters mammo performance in screening, diagnosis Ultrasound after DBT obviates diagnostic 2D mammo DBT maintains high performance over time DBT doesn't hurt screening throughput
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
Does the type and method of anesthesia administration used in breast cancer surgery impact recurrence-free survival?Anesthesiology
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Anesthesiology Journal Article Source Type: news
Authors: Raymond Eder ML, Rosa AL Abstract The surface of grapes lodges a complex community of yeast species responsible for spontaneous alcoholic fermentation. The study of indigenous Saccharomyces and "non-Saccharomyces" yeasts during grape must fermentation constitutes a major research area in microbial enology. Although there are detailed studies on the microbiota of Vitis vinifera L. grapes, little is known about the diversity of yeast communities present in non-vinifera Vitis ecosystems (i.e., grapes and spontaneously fermenting grape musts). Potentially scientific and/or enological valuable yeast s...
Source: Revista Argentina de Microbiologia - Category: Microbiology Tags: Rev Argent Microbiol Source Type: research
Authors: Nguyen Y, Stirnemann J, Belmatoug N Abstract Gaucher disease is a rare autosomal recessive genetic disease, caused by a deficiency of the lysosomal enzyme, glucocerebrosidase that leads to the accumulation of its substrate (glucosylceramide) in lysosomal macrophages. In the general population, its incidence varies between 0.4 and 5.8/100,000 inhabitants. Type 1 Gaucher disease is the most frequent and is characterized by its extreme heterogeneity including asymptomatic or more severe presentations. The most frequent symptoms are anemia, thrombocytopenia, splenomegaly, and/or hepatomegaly, and a potentially...
Source: Revue de Medecine Interne - Category: Internal Medicine Tags: Rev Med Interne Source Type: research
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