The role of FOXP3 in autoimmunity.

The role of FOXP3 in autoimmunity.
Curr Opin Immunol. 2016 Aug 18;43:16-23
Authors: Pesenacker AM, Cook L, Levings MK
Abstract
FOXP3 controls the development and function of T regulatory cells (Tregs). Autoimmunity is linked to changes in FOXP3 activity that can occur at multiple levels and lead to Treg dysfunction. For example, changes in IL-2 signaling, FOXP3 transcription and/or post-translational modifications can all contribute to loss of self-tolerance. As additional pathways of FOXP3 regulation are elucidated, new therapeutic approaches to increase Treg activity either by cell therapy or pharmacological intervention are being tested. Early success from pioneering studies of Treg-based therapy in transplantation has promoted the undertaking of similar studies in autoimmunity, with emerging evidence for the effectiveness of these approaches, particularly in the context of type 1 diabetes.
PMID: 27544816 [PubMed - as supplied by publisher]

Source: Current Opinion in Immunology - August 17, 2016 Category: Allergy & Immunology Authors: Pesenacker AM, Cook L, Levings MK Tags: Curr Opin Immunol Source Type: research