Malaria-Like Parasite From Ticks Spreading To U.K. Through Dogs

Mepron, a thick liquid antimicrobial drug used to treat Babesia and malaria, as well as a fungal infection called Pneumocystitis carinii. In 2011, the United Kingdom stopped requiring that dogs brought into the country be inspected for ticks. Earlier this year, several dogs tested positive for babesia, a malaria-like disease transmitted to ticks that previously had only been found in foreign. These dogs had never left the U.K. While babesiosis is a new worry to U.K. dog owners, it's been a threat to human beings for years -- it just hasn't become a health-scare-of-the-week like Zika, West Nile, avian and swine flu. Most people have never heard of it. Babesia microti, the protozoan that causes babesiosis, occurs throughout continental Europe and Asia, as well as throughout New England and northern Midwest regions -- the same areas in which Lyme disease is most often diagnosed. It's no coincidence: Lyme (Borrelia burgdorferi) and Babesia both are transmitted by ticks, along with a number of other pathogens. Like Lyme and Plague (bubonic plague), Babesia is a zoonotic illness, meaning that it is transmitted from non-human animal hosts to human hosts. Babesia microti is a tiny parasite that invade red blood cells. Many healthy individuals who contract Babesia don't show any symptoms. Among those who do, symptoms can be similar to the flu, including "fever, chills, sweats, headache, body aches, loss of appetite, nausea, or fatigue," according to the U.S. Centers for...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news

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ConclusionIs convenient to consider a medication induced AP in patients without clear causative agent, such as the VA case presented. An etiological diagnosis algorithm of exclusion is proposed, for an adequate therapeutic approach in medication induced PNH. Algorithm validation is required.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
Publication date: Available online 18 June 2019Source: Joint Bone SpineAuthor(s): François Vidal, André. Gillibert, Muriel Quillard, Patrice Fardellone, Olivier Vittecoq, Thierry Lequerré
Source: Joint Bone Spine - Category: Orthopaedics Source Type: research
In conclusion, co-infection of chicks with AIV and IBV, simultaneously or sequentially, affected the clinical signs, the virus replication dynamics as well as the internal organ integrity. The results proposed that infection with heterologous virus may result in temporary competition for cell receptors or competent cells for replication, most likely interferon-mediated.
Source: Comparative Immunology, Microbiology and Infectious Diseases - Category: Infectious Diseases Source Type: research
ConclusionsDGBX significantly alleviates abnormal tumor-induced EPC accumulation, inhibits B16 melanoma progression, and enhances anti-tumor immune responses.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
ConclusionsOverall results revealed that herbal plants may be active in the development of novel and cheap antimalarial compounds.
Source: Chinese Herbal Medicines - Category: Complementary Medicine Source Type: research
The common fruit fly, Drosophila melanogaster, is an outstanding model to study the molecular basis of anti-pathogen immunity. The parasitic nematode Heterorhabditis gerrardi, together with its mutualistic bacteria Photorhabdus asymbiotica, infects a wide range of insects, including D. melanogaster. Recently we have shown that Transforming Growth Factor-β (TGF-ß) signaling in D. melanogaster is regulated in response to parasitic nematode infection. In the current study, we investigated the contribution of two TGF-ß signaling branches, the activin and the Bone Morphogenic Protein (BMP), to D. melanogaster i...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
The molecular bases of the host-parasitoid interactions in the biological system Acyrthosiphon pisum (Harris) (Homoptera, Aphididae) - Aphidius ervi (Haliday) (Hymenoptera, Braconidae) have been elucidated allowing the identification of a gamma-glutamyl transpeptidase, the active component of maternal venom secretion, and teratocytes, the embryonic parasitic factors responsible for the host physiology regulation after parasitization. Teratocytes, cells deriving from the dissociation of serosa, the parasitoid embryonic membrane, are responsible for extra-oral digestion of host tissues in order to provide a suitable nutritio...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Middle East respiratory syndrome (MERS) is an emerging respiratory disease caused by the MERS coronavirus (MERS-CoV). MERS has been endemic to Saudi Arabia since 2012. The reservoir of MERS-CoV is the dromedary camel, suggesting that MERS is primarily a zoonotic disease. MERS-CoV is common in dromedaries throughout the Middle East, North Africa, and East Africa as evidenced by neutralizing antibodies against MERS-CoV; however, human cases have remained limited to the Middle East. To better understand the cause of this difference, the virological properties of African camel MERS-CoV were analyzed based on the spike (S) prot...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
An effective vaccine against the Plasmodium parasite is likely to require the induction of robust antibody and T cell responses. Chimeric virus-like particles are an effective vaccine platform for induction of antibody responses, but their capacity to induce robust cellular responses and protection against pathogen challenge when incorporating T cell epitopes has not been established. To evaluate this, we produced chimeric constructs using the murine polyomavirus structural protein with surface-exposed CD8+ or CD4+ T cell or B cell repeat epitopes derived from the Plasmodium yoelii circumsporozoite protein, and assessed im...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
Publication date: Available online 17 June 2019Source: Parasitology InternationalAuthor(s): Masako Fukuda, Shigehiko Uni, Takahiro Igari, Yasufumi Utsumi, Yasushi Otsuka, Jun Nakatani, Shoji Uga, Tatsuru Hara, Hideo Hasegawa, Hiroyuki TakaokaAbstractA 73-year-old man living in Kawamata-machi, Fukushima Prefecture, Northeastern Honshu, Japan, visited a hospital with complaints of a subcutaneous swelling that had developed on the back of his left hand. The nodule was surgically removed from the vagina fibrosa tendinis of his left forefinger. Based on the histopathological characteristics, the causative agent of this nodule w...
Source: Parasitology International - Category: Parasitology Source Type: research
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