Computational Prediction of RNA–RNA Interactions

We describe different tools and approaches for RNA–RNA interaction prediction. Recognition of ncRNA targets is predominantly governed by two principles, namely the stability of the duplex between the two interacting RNAs and the internal structure of both mRNA and ncRNA. Thus, approaches can be distinguished into different major categories depending on how they consider inter- and intramolecular structure. The first class completely neglects the internal structure and measures only the stability of the duplex. The second class of approaches abstracts from specific intramolecular structures and uses an ensemble-based approach to calculate the effect of internal structure on a putative binding site, thus measuring the accessibility of the binding sites.

Source: Springer protocols feed by Bioinformatics - December 4, 2013 Category: Bioinformatics Source Type: news