Intracellular and extracellular miRNome deregulation in cellular models of NAFLD or NASH: clinical implications

Nonalcoholic fatty liver disease (NAFLD) represents the most common chronic liver disease in industrialized countries. NAFLD has the potential to progress through the inflammatory phase of nonalcoholic steatohepatitis (NASH) to fibrosis, cirrhosis, and hepatocellular carcinoma. Identifying patients at risk for this transition is a relevant clinical challenge. The complexity of these phenotypes in vivo made necessary the development of in vitro models in order to dissect the molecular signalling affected in NAFLD and NASH, but also to identify potential circulating biomarkers.

Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - August 20, 2016 Category: Nutrition Authors: S. Di Mauro, M. Ragusa, F. Urbano, A. Filippello, A. Di Pino, A. Scamporrino, A. Pulvirenti, A. Ferro, A.M. Rabuazzo, M. Purrello, F. Purrello, S. Piro Source Type: research