Local control dependence on consecutive vs. nonconsecutive fractionation in lung stereotactic body radiation therapy.
CONCLUSION: Five-fraction SBRT delivered over non-consecutive days imparts superior LC and similar toxicity compared to consecutive fractionation. These results should be validated in independent datasets and in a prospective fashion. PMID: 27543255 [PubMed - as supplied by publisher]
Conditions: Metastatic Lung Non-Small Cell Carcinoma; Refractory Lung Non-Small Cell Carcinoma; Stage III Lung Cancer AJCC v8; Stage IIIA Lung Cancer AJCC v8; Stage IIIB Lung Cancer AJCC v8; Stage IIIC Lung Cancer AJCC v8; Stage IV Lung Cancer AJCC v8; U nresectable Lung Non-Small Cell Carcinoma Interventions: Drug: Atezolizumab 1200 MG in 20 ML ...
ConclusionsThis first report of SBRT for pulmonary LCNEC demonstrates that SBRT is a feasible modality for this rare disease. A multidisciplinary thoracic oncology approach involving medical oncology, thoracic surgery, radiation oncology and pulmonology is strongly recommended to ensure proper patient selection for receipt of SBRT.
CONCLUSIONS: Salvage SBRT for isolated local failures after initial SBRT appears safe, with low treatment-related toxicity and encouraging rates of tumor control. PMID: 31481272 [PubMed - as supplied by publisher]
Stereotactic body radiotherapy (SBRT) is an established treatment option in the management of patients with early-stage non-small cell lung cancer (NSCLC). Prospective studies have demonstrated that SBRT achieves high rates of local tumor control [1 –3]. Compared to conventionally-fractionated radiotherapy (CFRT) for early stage NSCLC, SBRT is associated with equivalent tumor control, shortened treatment times, and decreased toxicity, with larger retrospective studies even suggesting a survival benefit [4–7].
Conditions: Lung Non-Small Cell Carcinoma; Positive Surgical Margin; Resected Mass; Stage III Lung Cancer AJCC v8; Stage IIIA Lung Cancer AJCC v8; Stage IIIB Lung Cancer AJCC v8; Stage IIIC Lung Cancer AJCC v8; Stage IV Lung Cancer AJCC v8; Stage IVA Lung Cancer AJCC v8; Stage IVB Lung Cancer AJCC v8 Interventions: Other: Quality-of-Life&nb...