Overcoming the challenges of siRNA delivery: Nanoparticle strategies.

Overcoming the challenges of siRNA delivery: Nanoparticle strategies.
Curr Drug Deliv. 2016 Aug 16;
Authors: Shajari N, Mansoori B, Davudian S, Mohammadi A, Baradaran B
Abstract
RNA interference (RNAi) is a natural cellular process that can be operated to silence specific genes expression in post-transcriptional level by intracellular delivery of small interfering RNAs (siRNAs) and microRNAs. Therapeutics based on siRNA have an immense potential for the treatment of incurable diseases such as cancers. However, the in vivo utilization of siRNA and also the delivery of this agent to the target site is one of the most controversial challenges, the helpful assistance by nanoparticles can improve stable delivery and also enhance efficacy. More nanoparticle-based siRNA therapeutics is expected to become available in the near future. Herein, we have discussed the existing hurdles for systemic administration of siRNA as therapeutic agents and highlights the various strategies to overcome these hurdles, including chemical modification, lipid-based nanoparticles, and also briefly review polymeric nanoparticles.
PMID: 27538460 [PubMed - as supplied by publisher]

Source: Current Drug Delivery - August 15, 2016 Category: Drugs & Pharmacology Authors: Shajari N, Mansoori B, Davudian S, Mohammadi A, Baradaran B Tags: Curr Drug Deliv Source Type: research