State-of-the-art review of lithium poisoning: almost a must-read
4 out of 5 stars Lithium Poisoning: State of the Art. Baird-Gunning J et al. J Intensive Care Med 2016 Aug 11 [Epub ahead of print] Abstract This is a very good paper, the best comprehensive review I can remember reading on lithium. It is up to date, with 78 references as recent as 2015. A major reason I liked it so much is that the authors are quire frank about how much we don’t know, and resist giving, for instance, mandates about when to start hemodialysis based on lithium levels. This is a temptation that the authors of the recent ExTRIP review succumbed to. Interestingly, the two papers share an author (Sophie Gosselin). However, I think the authors missed — or at least failed to emphasize — a key point. With lithium poisoning, as with all toxicology cases, the key to successful treatment begins with basic ABCs and supportive care. This includes adequate hydration, which is crucial. There are many reasons why these patients — especially those with chronic lithium poisoning — present with significant and often under-appreciated volume depletion. The gastrointestinal manifestations of lithium toxicity include nausea, vomiting, and diarrhea. Because of these symptoms, along with lithium-induced mental status changes, fluid intake has typically been deficient. Because it can take days to weeks for chronic lithium toxicity to develop, this deficiency may have been going on for some time. In addition, chronic lithium poisonin...
Publication date: 12 April 2020Source: Nutrition, Metabolism and Cardiovascular Diseases, Volume 30, Issue 4Author(s): Huanhuan Wang, Ying Song, Xiaofang Tang, Jingjing Xu, Ping Jiang, Lin Jiang, Zhan Gao, Jue Chen, Lei Song, Yin Zhang, Xueyan Zhao, Shubin Qiao, Yuejin Yang, Runlin Gao, Bo Xu, Jinqing Yuan, Lijian Gao
Publication date: Available online 2 April 2020Source: Journal of the Formosan Medical AssociationAuthor(s): Chun-Wei Lee, Shu-Hao Wu, Wen-Chi Chiu, Shih-Tzer Tsai, Tzuo-Yun Lan
Authors: Alcázar-Leyva S, Zapata E, Bernal-Alcántara D, Gorocica P, Alvarado-Vásquez N Abstract Although thiamine pyrophosphate (TPP) is considered a protective agent for endothelial cells, it is still unknown if this is associated with nitric oxide (NO) synthesis. Our aim was to evaluate the synthesis of NO in endothelial cells incubated with TPP and high glucose concentrations. Endothelial cells from the umbilical cord vein from newborns (n = 20), were incubated with 5, 15 or 30 mmol/L glucose, in absence or presence of 0.625 mg/ml of TPP. Our results showed a significant...
Publication date: Available online 3 April 2020Source: Microbial PathogenesisAuthor(s): González Juliana, Cadona Jimena, Sanso Mariel, Bustamante Ana
Publication date: Available online 2 April 2020Source: Journal of Global Antimicrobial ResistanceAuthor(s): Pengcheng Du, Dejun Liu, Huangwei Song, Pei Zhang, Ruichao Li, Yulin Fu, Xiao Liu, Jinli Jia, Xiaodi Li, Séamus Fanning, Yang Wang, Li Bai, Hui Zeng
In this study, we aimed to analyze the expression of glycan-processing genes in DRG neurons from a leptin-deficient genetic mouse model of diabetes (db/db). Transcriptomic analysis revealed that several glycan-processing genes encoding for glycosyltransferases and sialic acid-modifying enzymes were upregulated in diabetic conditions. Functional analysis of these enzymes on recombinant Cav3.2 revealed an unexpected loss-of-function of the channel. Collectively, our data indicate that diabetes is associated with an alteration of the glycosylation machinery in DRG neurons. However, individual action of these enzymes when test...
DIABETES type 2 symptoms include feeling very tired, unexplained weight loss, and passing more urine than normal. But you could also be at risk of high blood sugar signs if you pass more urine than normal - how many toilet trips a day is normal?
Publication date: Available online 2 April 2020Source: Diabetes &Metabolic Syndrome: Clinical Research &ReviewsAuthor(s): Samit Ghosal, Sumit Sengupta, Milan Majumder, Binayak Sinha
DiabetesMine gets hands on, testing out powdered glucose packets for treating low blood sugar with diabetes.
Publication date: Available online 2 April 2020Source: Pharmacological ResearchAuthor(s): Ke Su, Bo Yi, Bi-qing Yao, Tian Xia, Yi-fei Yang, Zhi-hao Zhang, Cheng Chen