Cytotoxic and antimalarial constituents from aerial parts of Sphaeranthus indicus

Publication date: September 2016 Source:Phytochemistry Letters, Volume 17 Author(s): Watchara Sangsopha, Ratsami Lekphrom, Somdej Kanokmedhakul, Kwanjai Kanokmedhakul Two new eudesmanolide type sesquiterpenes, indicusalactone (1) and (−)​-​oxyfrullanolide (2), along with twelve known compounds (3–14), were isolated from the aerial parts of Sphaeranthus indicus. The structures of these compounds were established on the basis of their 1D and 2D NMR spectroscopic data. Compounds 1–4 and 12–14 showed antimalarial activity against Plasmodium falciparum with IC50 values ranging from 2.32 to 6.47μg/mL. In addition, compounds 2–5 showed cytotoxicity against cancer cell lines, KB, NCI-H187 and MCF-7 with IC50 values within the range 1.23–46.19μg/mL. Graphical abstract
Source: Phytochemistry Letters - Category: Chemistry Source Type: research