Urinary paracetamol and time-to-pregnancy
STUDY QUESTION
Is preconception urinary paracetamol (acetaminophen) associated with time-to-pregnancy (TTP)?
SUMMARY ANSWER
Higher urinary paracetamol concentrations among male partners were associated with a longer TTP.
WHAT IS KNOWN ALREADY
Paracetamol is a commonly used analgesic among women and men of all ages. As metabolites of select chemicals used in the manufacturing of polyurethane foam, dyes and various industrial products, as well as a common medicinal product, paracetamol and its primary metabolite p-aminophenol, are ubiquitous in the environment. Studies investigating the relationship between adult urinary concentrations of paracetamol and TTP are lacking.
STUDY DESIGN, SIZE, DURATION
This prospective cohort included 501 couples discontinuing contraception for the purposes of attempting conception during the years 2005–2009 and residing in Michigan or Texas, USA.
PARTICIPANTS/MATERIALS, SETTING, METHODS
Total urinary paracetamol, its metabolite para-aminophenol (p-aminophenol), and a summary measure of both urinary biomarkers were quantified by ultra-performance liquid chromatography coupled with an electrospray triple quadrupole mass spectrometry (UPLC-ESI-MS/MS). Female partners used the Clearblue® digital home test to confirm pregnancy. Cox's proportional odds models for discrete survival time were used to estimate fecundability odds ratios (FORs) and 95% confidence intervals (CIs), adjusting for age, body mass index (BMI), urinary creatinine, pr...
Source: Human Reproduction - Category: Reproduction Medicine Authors: Smarr, M. M., Grantz, K. L., Sundaram, R., Maisog, J. M., Honda, M., Kannan, K., Buck Louis, G. M. Tags: Reproductive epidemiology Source Type: research
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