Program Expansion Supplement: Provision of Male Medical Circumcision (MMC) in South Africa under PEPFAR

Funding Opportunity ID: 287641 Opportunity Number: CDC-RFA-GH11-11500503SUPP16 Opportunity Title: Program Expansion Supplement: Provision of Male Medical Circumcision (MMC) in South Africa under PEPFAROpportunity Category: DiscretionaryOpportunity Category Explanation: Funding Instrument Type: Cooperative AgreementCategory of Funding Activity: HealthCategory Explanation: CFDA Number(s): 93.067Eligible Applicants: Others (see text field entitled "Additional Information on Eligibility" for clarification)Additional Information on Eligibility: The eligible entities for this announcement are listed below: South African Clothing and Textile Workers Union (SACTWU)Agency Code: HHS-CDC-CGHAgency Name: Department of Health and Human ServicesCenters for Disease Control - CGHPosted Date: Aug 18, 2016Close Date: Oct 17, 2016 Electronically submitted applications must be submitted no later than 11:59 p.m., ET, on the listed application due date.Last Updated Date: Aug 18, 2016Award Ceiling: $5,489,235Award Floor: $0Estimated Total Program Funding: $5,489,235Expected Number of Awards: 1Description: VMMC is a one-time procedure that reduces men’s risk of acquiring HIV from heterosexual exposure for a lifetime. Three randomized controlled trials (RCT) demonstrated that VMMC reduces men’s risk of HIV acquisition by approximately 60%, making it one of the most effective HIV prevention interventions known. Extended follow-up of participants in the Uganda and Kenya...
Source: Grants.gov - Category: Research Tags: Health Source Type: funding

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Authors: Montazeri K, Bellmunt J Abstract Introduction: Since the approval of immune checkpoint inhibitors (ICIs), there has been continuing and significant progress in urothelial cancer (UC) treatment. However, only about one fifth of UC patients respond to ICI. Recently, erdafitinib was developed for treating locally advanced or metastatic UC (mUC) with FGFR3 or FGFR2 alterations, accounting for 15-20% of patients. Erdafitinib is the first targeted therapy ever approved for mUC.Areas covered: This review summarizes the preclinical and clinical data on erdafitinib for UC. PubMed search and relevant articles presen...
Source: Expert Review of Clinical Pharmacology - Category: Drugs & Pharmacology Tags: Expert Rev Clin Pharmacol Source Type: research
Authors: Jakubowska K, Koda M, Kisielewski W, KaƄczuga-Koda L, Famulski W Abstract The presence of tumor cells in the large intestine stimulates hypoxia and local inflammatory mediators that activate numerous inflammatory cells, including a diverse lymphoid tumor cell population. The aim of the present study was to evaluate tumor-infiltrating lymphocytes (TILs) located in the invasive primary tumor, surrounding deposits of tumor cells and those present in distal metastatic cells in the liver of patients with colorectal cancer. Furthermore, the correlation of TILs with anatomical parameters was assessed. The study ...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
The objective of the present study was to evaluate the beneficial effect of endorectal power Doppler/grayscale ultrasound-guided biopsy over that of mpMRI/TRUS-guided biopsy for decision-making regarding prostatectomy in males with a high risk of prostate cancer. Data regarding endorectal power Doppler/grayscale ultrasound-guided biopsies and mpMRI/TRUS-guided biopsies of 1,094 males with elevated specific prostate antigen, were included. Radical prostatectomy was performed in males aged
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
July 23, 2018A simple procedure is lowering the risk for thousands of couples in  Tanzania.Twenty-one-year-old Khadija Butemi was doing her morning chores when she heard an announcement through a loudspeaker passing by on the nearby country road.There was a campaign going on, it said, for men who wanted to undergo voluntary medical male circumcision (VMMC). She immediately thought of her husband, a 22-year-old fisherman, who was down by the lake fishing.The couple lives with their two-year-old daughter in Nansio, a remote village on the island of Ukerewe, Tanzania. VMMC isn ’t routinely offered in the area, and ...
Source: IntraHealth International - Category: International Medicine & Public Health Authors: Source Type: news
By Susan Blumenthal, M.D. and Alexandrea Adams The recent commemoration of National Women’s Health Week provided an important time to mark the progress that has been made in advancing women’s health over the past two decades and to highlight what more needs to be done to achieve women’s health equity in America. Historically, women have experienced discrimination in health care despite making 80 percent of health care decisions for their families, using more medical services than men, and suffering greater disability from chronic disease. Before the mid 1990’s, women were often excluded as subjects ...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
Funding Opportunity ID: 287592 Opportunity Number: CDC-RFA-GH15-15370201SUPP16 Opportunity Title: Program Expansion Supplement: Technical Assistance to Provide High-Quality Voluntary Medical Male Circumcision (VMMC) Services to Programs Supported by the President's Emergency Plan for AIDS Relief (PEPFAR)Opportunity Category: DiscretionaryOpportunity Category Explanation: Funding Instrument Type: Cooperative AgreementCategory of Funding Activity: HealthCategory Explanation: CFDA Number(s): 93.067Eligible Applicants: Others (see text field entitled "Additional Information on Eligibility" for clarification)A...
Source: Grants.gov - Category: Research Tags: Health Source Type: funding
Funding Opportunity ID: 286885 Opportunity Number: CDC-RFA-GH11-11100501SUPP16 Opportunity Title: Program Expansion Supplement: Supporting Health Worker Staffing in South Africa under PEPFAROpportunity Category: DiscretionaryOpportunity Category Explanation: Funding Instrument Type: Cooperative AgreementCategory of Funding Activity: HealthCategory Explanation: CFDA Number(s): 93.067Eligible Applicants: Others (see text field entitled "Additional Information on Eligibility" for clarification)Additional Information on Eligibility: Eligible applicants that can apply for this funding opportunity are listed be...
Source: Grants.gov - Category: Research Tags: Health Source Type: funding
Conclusions The results from this analysis reveal that contrary to expectation, efficiency gains from the integration of HIV and SRH services, if any, are likely to be modest. Efficiency gains are likely to be most achievable in settings that are currently delivering HIV and SRH services at a low scale with high levels of fixed costs. The presence of cost complementarities for only three service combinations implies that careful consideration of setting-specific clinical practices and the extent to which they can be combined should be made when deciding which services to integrate. Trial registration number NCT01694862.
Source: Sexually Transmitted Infections - Category: Sexual Medicine Authors: Tags: Health policy, Open access, Drugs: infectious diseases, HIV/AIDS, Cervical cancer, Cervical screening, Contraception, Family planning, Gynecological cancer, Screening (oncology), HIV / AIDS, HIV infections, Vulvovaginal disorders, Screening (epidemiology) Source Type: research
Anogenital preinvasive and invasive lesions are known to have been on the increase in the industrialised world since the 1970s.1 The increase in anal squamous cell carcinomas and Kaposi's sarcomas (KS) has often been associated with the HIV epidemic, especially among men having sex with men. KS and non-Hodgkin's lymphoma are virus-related (KS-associated herpes virus and Epstein–Barr, respectively) AIDS-defining illnesses.2 Among anogenital cancers, only cervical cancer is listed as AIDS-defining illness. A large proportion of anogenital preinvasive and invasive lesions are human papillomavirus (HPV)-related, with a v...
Source: Sexually Transmitted Infections - Category: Sexual Medicine Authors: Tags: Letter Source Type: research
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