Conditions with Confusing Names
Spondylolysis, Spondylolisthesis, Spondylitis &Spondylosis These four conditions affect the lumbar spine and may be confusing. What is the difference between spondylolysis, spondylolisthesis, spondylitis, and spondylosis? Spondylolysis (pars interarticularis Defect) - Used to describe the anatomic defect or break of the pars interarticularis of the vertebral arch. Spondylolysis usually occurs in the lower lumbar spine, especially the L5 vertebrae. It usually appears as a radiolucent gap on lateral X-ray. It occurs in about 5% of the population; it is not present at birth but develops over time and may run in families. Spondylolysis is usually caused due to repetitive trauma, especially hyperextension. Repetitive trauma may cause stress fractures. The condition is usually asymptomatic; patient may have activity related low back pain or hamstring tightness. AP and lateral X-rays may show defect in about 80% of cases. It may show as a defect with or without sclerosis. Oblique views may add another 15% more to the diagnosis. The "scotty dog" sign refers to the normal appearance of the lumbar spine, when seen on oblique radiographic projection. If spondylolysis is present, the pars interarticularis, or the neck of the dog, will have a defect or break (as if the dog has a collar around the neck). CT scan is the best study, especially to check for healing. A SPECT scan is the best study when X-rays are negative and strongly suspect the condition. Lysis means dis...
Authors: Ravalli S, Szychlinska MA, Lauretta G, Di Rosa M, Musumeci G Abstract Introduction: Osteoarthritis (OA) is a degenerative disease which primarily affects hyaline cartilage, leading to pain, stiffness and loss of mobility of the entire articulation. Diagnosis is commonly based on symptoms and radiographs, but there is a growing interest in detecting novel biomarkers, in serum, urine and synovial fluid, which can be predictors of disease onset and progression.Areas covered: This review provides an overview of the main biomarkers currently used in OA clinical practice, with a focus on lubricin, a surface glyc...
In this study, a wireless slot-antenna integrated temperature-pressure-humidity (TPH) sensor loaded with complementary split ring resonator (CSRR) for harsh-environment applications was presented. The sensor is a multi-resonance structure with three separate resonant frequencies, which renders simultaneous measurements of temperature, pressure and humidity by placing sensitive elements in the corresponding CSRR structures. The sensitivity mechanisms for the temperature, pressure and humidity sensing are described in detail. The sensor was customized and fabricated on the high temperature co-fired ceramics (HTCC) using the ...
My fellowship program director told me that they used USMLE scores to rank applicants.
ConclusionsCT ‐guided biopsy is a safe and highly accurate diagnostic method for SCLNs.
CONCLUSIONS: The 2019 EULAR/ACR criteria for SLE had comparable performance to the 2012 SLICC criteria regarding diagnostic sensitivity and specificity in Korean population of SLE and other rheumatic diseases. However, the new criteria could not reach higher specificity than the 2012 SLICC criteria. PMID: 32083550 [PubMed - as supplied by publisher]
Authors: Wang H, Liu Z, Shen Z, Fang L, Zhang S Abstract OBJECTIVES: To identify the predictors of coronary involvement, and to determine the impact of coronary involvement on long-term outcomes in patients with Takayasu's arteritis (TAK). METHODS: This retrospective cohort study of TAK patients with coronary evaluation by angiography or computed tomography angiography was conducted in a tertiary center between 1990 and 2018. Risk factors for coronary involvement and predictors of overall survival, cardiovascular event-free survival, and relapse-free survival were investigated. RESULTS: The median follow-up...
CONCLUSIONS: Testing for autoantibodies against both Ro peptides may aim diagnosis, classify clinical manifestations in disease entities and define prognosis in certain autoimmune disorders. A distinct weight could be given to the isolated anti-Ro specificities in the SS classification criteria. PMID: 32083547 [PubMed - as supplied by publisher]
CONCLUSIONS: We found DEGs and DEMs in FM patients through bioinformatics analysis, which may be involved in the occurrence and development of FM and serve as potential targets for diagnosis and treatment. PMID: 32083545 [PubMed - as supplied by publisher]
CONCLUSIONS: In this cohort the most frequent damage item was renal and was related to the disease itself. Damage score was higher in patients with more severe disease and treated more aggressively. Our results suggest that more effective treatment options are needed in a subgroup of patients with IgA vasculitis to prevent the damage related with the vasculitis, especially with more severe disease. PMID: 32083544 [PubMed - as supplied by publisher]
CONCLUSIONS: Our findings suggest that improvement in MMP-3 levels is key to predicting the clinical efficacy of abatacept. Closer attention paid not only to major clinical indices, but also changes in MMP-3 levels, could improve our ability to optimise clinical results when treating bio-switch patients. PMID: 32083543 [PubMed - as supplied by publisher]
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