Penn team identifies strategy to reverse the disease dyskeratosis congenita

(University of Pennsylvania) In a new study published in Cell Stem Cell, researchers from the University of Pennsylvania led by Christopher J. Lengner of the School of Veterinary Medicine and Brad Johnson of the Perelman School of Medicine have found a link between telomeres and a molecular signaling cascade called the Wnt pathway that may point to a treatment option for dyskeratosis congenita patients.
Source: EurekAlert! - Medicine and Health - Category: Global & Universal Source Type: news

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ConclusionThere is evidence that newborns have a much higher potential for wound healing than adults. Proper position in long-term immobilization of toes is important to prevent scar contracture and deformity.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
Authors: Kobbe G, Schroeder T, Rautenberg C, Kaivers J, Gattermann N, Haas R, Germing U Abstract Introduction: Myelodysplastic Syndromes (MDS) are a heterogeneous group of myeloid neoplasms arising in a multipotent hematopoietic stem cell. In about 50% of cases, chromosomal aberrations are detected, which can serve as clonal markers as well as important prognostic factors. In recent years, many somatic mutations have been recognized to be involved in the initiation and clonal evolution of MDS. They provide prognostic information, not only regarding the natural course of disease but also regarding the outcome of all...
Source: Expert Review of Hematology - Category: Hematology Tags: Expert Rev Hematol Source Type: research
In this study, we compared the effect of transplantation of isolated Sca-1+ cells and c-Kit+ cells with that of the crude CDCs (CrCDCs). Focusing on the differences in the ability for secretion of paracrine factors among 3 types of cells, we determined the effects of transplantation of these cells on cardiac intracellular signaling and mitochondrial function in rats with permanently ligated coronary arteries. We showed that the transplantation of these cells resulted in a preservation of the cardiac pump function and mitochondrial respiration at the 8th week after myocardial infarction. However, mitochondrial function in t...
Source: Journal of Pharmacological Sciences - Category: Drugs & Pharmacology Source Type: research
Authors: Yin X, Yang J, Liu Y, Zhang J, Xin C, Zhao H, Wang W, Shi X, Cui Z, Li G, Zhao C, Liu X Abstract The current study aimed to explore the levels of leptin (LEP) and LEP receptor (LEP-R) on the progression of aplastic anemia (AA) with bone marrow fat conversion. An AA model was developed by infusing C57BL/6 lymph node cells into BALB/c mice. At 0, 3, 6, 9, 12, 15 and 18 days after modeling, routine blood counts, bone marrow biopsy slides, lymphocyte subsets (CD4+ and CD8+ T cells) and cytokine levels [including interleukin (IL)-2, IL-4, IL-5 and interferon-γ] were assessed. LEP and LEP-R levels in perip...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
In conclusion, the present study demonstrated that CGRP administration increased new bone formation, possibly via enhancing BMMSC migration and differentiation in MDO rats. PMID: 31316600 [PubMed]
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
Publication date: Available online 19 July 2019Source: Stem Cell ResearchAuthor(s): Haiyan Zhang, Yanyan Ma, Fengling Song, Xiaomeng Yang, Yue Li, Jingyun Guan, Yuqiang Lv, Min Gao, Jian Ma, Yi Liu, Zhongtao GaiAbstractAn induced pluripotent stem cell (iPSC) line was generated from peripheral blood mononuclear cells from a 27-month-old boy with short rib-thoracic dysplasia syndrome type III carrying compound heterozygous mutations (c.940T>C(p.W314R) and c.10163C>T(p.P3388L)) in DYNC2H1. The iPSCs have a normal karyotype, and express pluripotency markers and bear differentiation potential in vitro.
Source: Stem Cell Research - Category: Stem Cells Source Type: research
Publication date: November 2019Source: Materials Science and Engineering: C, Volume 104Author(s): Han Wang, Kexin Su, Leizheng Su, Panpan Liang, Ping Ji, Chao WangAbstractMetals such as Ta (tantalum) and Ti (titanium) have been popularly used as a bone substitute or implants in orthopedic surgery and dentistry, since they have excellent corrosion. For manufacturing porous implants with precise structure, SLM (Selective laser melting), which is one of the 3D (three-dimensional) printing techniques, is always be chosen. To compare biological performances between porous Ta and Ti implants, we designed them with the same poros...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
In conclusion, we showed that exosome uptake at peripheral nerve endings and retrograde transport of exosomes to DRG neurons and spinal cord motor neurons in the anterior horn can occur. In addition, our findings propose a novel drug delivery approach for treating neuronal diseases. PMID: 31317777 [PubMed - in process]
Source: Artificial Cells, Nanomedicine and Biotechnology - Category: Biotechnology Tags: Artif Cells Nanomed Biotechnol Source Type: research
This reporter cell line may be used to study the development of mDA neurons or to enrich mDA populations for transplantation.
Source: Stem Cell Research - Category: Stem Cells Source Type: research
Publication date: Available online 18 July 2019Source: Stem Cell ResearchAuthor(s): Mohsina Khan, Samruddhi Zende, Arun Vaidyanath, Rasika Avatade, Anjali ShirasAbstractHuman induced pluripotent stem cell-lines (iPSCs) of Indian origin NCCSi005A and NCCSi006A were established by reprogramming of CD4+T cells, isolated from the peripheral blood mononuclear cells (PBMCs) of two healthy female donors. Reprogramming was achieved using integration free, Sendai viral vector system expressing cocktail of transcription factors KOS, hc-MYC and hKLF4. Both the established cell-lines showed alkaline phosphatase activity, expressed ste...
Source: Stem Cell Research - Category: Stem Cells Source Type: research
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