Program Expansion Supplement: Provision of Male Medical Circumcision (MMC) in South Africa under PEPFAR

Funding Opportunity ID: 287657 Opportunity Number: CDC-RFA-GH11-11500501SUPP16 Opportunity Title: Program Expansion Supplement: Provision of Male Medical Circumcision (MMC) in South Africa under PEPFAROpportunity Category: DiscretionaryOpportunity Category Explanation: Funding Instrument Type: Cooperative AgreementCategory of Funding Activity: HealthCategory Explanation: CFDA Number(s): 93.067Eligible Applicants: Others (see text field entitled "Additional Information on Eligibility" for clarification)Additional Information on Eligibility: The eligible entities for this announcement are listed below: JHPIEGOAgency Code: HHS-CDC-CGHAgency Name: Department of Health and Human ServicesCenters for Disease Control - CGHPosted Date: Aug 18, 2016Close Date: Oct 17, 2016 Electronically submitted applications must be submitted no later than 11:59 p.m., ET, on the listed application due date.Last Updated Date: Aug 18, 2016Award Ceiling: $832,078Award Floor: $0Estimated Total Program Funding: $832,078Expected Number of Awards: 1Description: This Funding Opportunity Announcement (FOA) seeks to provide additional funds to The South African Clothing and Textile Workers Union (SACTWU – GH000265), Jhpiego (GH000237) and Population Services International (PSI- GH000248) for the purpose of scale-up of voluntary medical male circumcision (VMMC) services to 27 high-burden districts, as well as sub-districts with low male circumcision (MC) prevalence. VMMC is a one-time...
Source: Grants.gov - Category: Research Tags: Health Source Type: funding

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Molecular Mechanisms of Notch Signaling in Lymphoid Cell Lineages Development: NF-κB and Beyond. Adv Exp Med Biol. 2020;1227:145-164 Authors: Tsaouli G, Barbarulo A, Vacca A, Screpanti I, Felli MP Abstract Notch is a ligand-receptor interaction-triggered signaling cascade highly conserved, that influences multiple lineage decisions within the hematopoietic and the immune system. It is a recognized model of intercellular communication that plays an essential role in embryonic as well as in adult immune cell development and homeostasis. Four members belong to the family of Notch receptors (Notch1-4...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
Authors: Aradhya R, Jagla K Abstract Notch plays multiple roles both in development and in adult tissue homeostasis. Notch was first identified in Drosophila in which it has then been extensively studied. Among the flag-ship Notch functions we could mention its capacity to keep precursor and stem cells in a nondifferentiated state but also its ability to activate cell proliferation that in some contexts could led to cancer. In general, both these functions involve, canonical, ligand-dependent Notch activation. However, a ligand-independent Notch activation has also been described in a few cellular contexts. Here, w...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
Authors: Salviano-Silva A, Berti FCB, Lobo-Alves SC, de Araujo-Souza PS, Boldt ABW, Malheiros D Abstract The Notch signaling is a crucial pathway involved in cellular development, progression, and differentiation. Deregulation of Notch signaling pathway commonly impacts tissue homeostasis, being highly associated with proliferative disorders. The long noncoding RNAs (lncRNAs), which are transcripts with more than 200 nucleotides that do not code for proteins, were already described as Notch signaling pathway-interacting molecules. Many of them act as important transcriptional and posttranscriptional regulators, aff...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
July 23, 2018A simple procedure is lowering the risk for thousands of couples in  Tanzania.Twenty-one-year-old Khadija Butemi was doing her morning chores when she heard an announcement through a loudspeaker passing by on the nearby country road.There was a campaign going on, it said, for men who wanted to undergo voluntary medical male circumcision (VMMC). She immediately thought of her husband, a 22-year-old fisherman, who was down by the lake fishing.The couple lives with their two-year-old daughter in Nansio, a remote village on the island of Ukerewe, Tanzania. VMMC isn ’t routinely offered in the area, and ...
Source: IntraHealth International - Category: International Medicine & Public Health Authors: Source Type: news
By Susan Blumenthal, M.D. and Alexandrea Adams The recent commemoration of National Women’s Health Week provided an important time to mark the progress that has been made in advancing women’s health over the past two decades and to highlight what more needs to be done to achieve women’s health equity in America. Historically, women have experienced discrimination in health care despite making 80 percent of health care decisions for their families, using more medical services than men, and suffering greater disability from chronic disease. Before the mid 1990’s, women were often excluded as subjects ...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
Funding Opportunity ID: 287641 Opportunity Number: CDC-RFA-GH11-11500503SUPP16 Opportunity Title: Program Expansion Supplement: Provision of Male Medical Circumcision (MMC) in South Africa under PEPFAROpportunity Category: DiscretionaryOpportunity Category Explanation: Funding Instrument Type: Cooperative AgreementCategory of Funding Activity: HealthCategory Explanation: CFDA Number(s): 93.067Eligible Applicants: Others (see text field entitled "Additional Information on Eligibility" for clarification)Additional Information on Eligibility: The eligible entities for this announcement are listed below: Sout...
Source: Grants.gov - Category: Research Tags: Health Source Type: funding
Funding Opportunity ID: 287592 Opportunity Number: CDC-RFA-GH15-15370201SUPP16 Opportunity Title: Program Expansion Supplement: Technical Assistance to Provide High-Quality Voluntary Medical Male Circumcision (VMMC) Services to Programs Supported by the President's Emergency Plan for AIDS Relief (PEPFAR)Opportunity Category: DiscretionaryOpportunity Category Explanation: Funding Instrument Type: Cooperative AgreementCategory of Funding Activity: HealthCategory Explanation: CFDA Number(s): 93.067Eligible Applicants: Others (see text field entitled "Additional Information on Eligibility" for clarification)A...
Source: Grants.gov - Category: Research Tags: Health Source Type: funding
Funding Opportunity ID: 286885 Opportunity Number: CDC-RFA-GH11-11100501SUPP16 Opportunity Title: Program Expansion Supplement: Supporting Health Worker Staffing in South Africa under PEPFAROpportunity Category: DiscretionaryOpportunity Category Explanation: Funding Instrument Type: Cooperative AgreementCategory of Funding Activity: HealthCategory Explanation: CFDA Number(s): 93.067Eligible Applicants: Others (see text field entitled "Additional Information on Eligibility" for clarification)Additional Information on Eligibility: Eligible applicants that can apply for this funding opportunity are listed be...
Source: Grants.gov - Category: Research Tags: Health Source Type: funding
Conclusions The results from this analysis reveal that contrary to expectation, efficiency gains from the integration of HIV and SRH services, if any, are likely to be modest. Efficiency gains are likely to be most achievable in settings that are currently delivering HIV and SRH services at a low scale with high levels of fixed costs. The presence of cost complementarities for only three service combinations implies that careful consideration of setting-specific clinical practices and the extent to which they can be combined should be made when deciding which services to integrate. Trial registration number NCT01694862.
Source: Sexually Transmitted Infections - Category: Sexual Medicine Authors: Tags: Health policy, Open access, Drugs: infectious diseases, HIV/AIDS, Cervical cancer, Cervical screening, Contraception, Family planning, Gynecological cancer, Screening (oncology), HIV / AIDS, HIV infections, Vulvovaginal disorders, Screening (epidemiology) Source Type: research
Anogenital preinvasive and invasive lesions are known to have been on the increase in the industrialised world since the 1970s.1 The increase in anal squamous cell carcinomas and Kaposi's sarcomas (KS) has often been associated with the HIV epidemic, especially among men having sex with men. KS and non-Hodgkin's lymphoma are virus-related (KS-associated herpes virus and Epstein–Barr, respectively) AIDS-defining illnesses.2 Among anogenital cancers, only cervical cancer is listed as AIDS-defining illness. A large proportion of anogenital preinvasive and invasive lesions are human papillomavirus (HPV)-related, with a v...
Source: Sexually Transmitted Infections - Category: Sexual Medicine Authors: Tags: Letter Source Type: research
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