After Moyamoya surgery, a back-to-normal birthday for Carolyn

Before Moyamoya surgery Carolyn Milks turns 8 on August 21. It’s a big celebration. Carolyn and her family aren’t just celebrating her birthday — they’re celebrating Carolyn’s return to normal. For most of the summer, things like swimming, riding her bicycle and horsing around with her sisters and cousins had been out of the question for Carolyn. But on August 11, Dr. Ed Smith, co-director of the Boston Children’s Hospital Cerebrovascular Surgery and Interventions Center, gave Carolyn the green light. She could go back to being a kid. “This is what kids really want. They just want to be normal and do their normal activities,” says Carolyn’s mother Kristen. It had been a topsy-turvy spring for the Milks family. My heart and mind froze. Her whole left side was weak. … Only one part of the body controls both the arm and the leg. I thought, ‘Carolyn has something wrong with her brain.’ Carolyn, normally a bright, active second grader, started having puzzling symptoms in March. “She was having a hard time concentrating on her homework and was crying, and my husband and I couldn’t figure out why,” recalls Kristen. Over the next few days Kristen, an occupational therapist, began observing strange movements in her daughter’s left arm and hand. Carolyn appeared to struggle with everyday activities like holding a pencil, tying her shoes, and she even tried to switch her hand dominance....
Source: Thrive, Children's Hospital Boston - Category: Pediatrics Authors: Tags: Our Patients’ Stories Boston Children's at Waltham Cerebrovascular Surgery and Interventions Center Dr. Ed Smith moyamoya Source Type: news

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Publication date: Available online 20 October 2019Source: International Journal of PsychophysiologyAuthor(s): Eliana Vassena, Filip Van Opstal, Ingeborg Goethals, Tom VergutsAbstractThe ability to exert control has been widely investigated as a hallmark of adaptive behaviour. Dopamine is recognized as the key neuromodulator mediating various control-related processes. The neural mechanisms underlying the subjective perception of being in control, or Locus of Control (LOC) are however less clear. LOC indicates the subjective tendency to attribute environmental outcomes to one's actions (internal LOC) or instead to external ...
Source: International Journal of Psychophysiology - Category: Psychiatry & Psychology Source Type: research
Objective: To compare the rate of malreduction after high fibular fractures associated with syndesmosis injury treated with open reduction and internal fixation, with either 2 screws or 1 knotless TightRope device. Design: Prospective randomized controlled multicenter trial. Setting: Eleven academic and community hospitals including Level 1 and Level 2 trauma centers across Canada. Patients/Participants: One hundred three patients with OTA/AO 44-C injuries with demonstrated radiographic syndesmosis diastasis or instability after malleolar bony fixation were followed for 12 months after treatment. Methods: Ope...
Source: Journal of Orthopaedic Trauma - Category: Orthopaedics Tags: Original Article Source Type: research
Source: BMJ Comments - Category: General Medicine Source Type: forums
Source: BMJ Comments - Category: General Medicine Source Type: forums
CONCLUSIONS: Overall, hypothermia offers clinical benefit, most likely through its effects on the inflammatory response.
Source: Clinics - Category: General Medicine Source Type: research
CONCLUSION: A substantial proportion of infants diagnosed with CF after detection by NBS already showed evidence of lung disease. P. aeruginosa colonization was associated with increas ed Bhalla scores, highlighting the importance of this CF pathogen in early structural lung disease. The presence of bronchial wall thickening at such a young age may reflect the presence of airway inflammatory processes. The detection and quantification of structural abnormalities with the modified Bhalla score may aid in the identification of lung disease before it is clinically apparent.
Source: Clinics - Category: General Medicine Source Type: research
Conclusion: The use of TPB constructs in the development of oral health promotions aimed at parents of preschoolers was partially supported. Intention and behavior were not affected post-intervention, but SN and PBC emerged as significant predictors of intentions and behavior. A dental smartphone app may aid parents to make good oral health habits part of their preschooler's daily routine. PMID: 31628171 [PubMed - in process]
Source: Journal of Dental Hygiene - Category: Dentistry Tags: J Dent Hyg Source Type: research
Publication date: Available online 20 October 2019Source: Blood Cells, Molecules, and DiseasesAuthor(s): Seung Hyun Son, Ji Min Oh, Prakash Gangadaran, Hyun Dong Ji, Ho Won Lee, Ramya Lakshmi Rajendran, Se Hwan Baek, Arunnehru Gopal, Senthilkumar Kalimuthu, Shin Young Jeong, Sang-Woo Lee, Jaetae Lee, Byeong-Cheol AhnAbstractBackgroundExtracellular vesicles, have gained increasing attention for their application in drug delivery. Here, we developed a novel method for radiolabeling WBCs with 99mTc using RBC-derived extracellular vesicles -mimetics (EVMs), and monitored in vivo inflammation tracking of 99mTc-WBC using gamma c...
Source: Blood Cells, Molecules, and Diseases - Category: Hematology Source Type: research
CCR Grand Rounds Dr. Jabado ’ s research focuses on elucidating genetic signatures of pediatric astrocytomas and examining how they compare to adults. These are deadly brain tumors that originate in the brain and include glioblastomas (GBM, the highest grade of astrocytomas), which are one of the deadliest cancers in humans. Her group uncovered that pediatric high-grade astrocytomas (HGA) are molecularly and genetically distinct from adult tumors. They also identified a new molecular mechanism driving pediatric HGA, namely recurrent somatic driver mutations in the tail of histone 3 variants (H3.3 and H3.1). These mut...
Source: Videocast - All Events - Category: General Medicine Tags: Upcoming Events Source Type: video
For most people, the process of blood donation appears simple and straightforward: you lounge on a chair for 20-30 minutes as your blood collects into a bag, grab a cookie and some juice, then head back to the rest of your day. Behind the scenes, how...
Source: Medgadget - Category: Medical Devices Authors: Tags: Emergency Medicine Exclusive Public Health Surgery Source Type: blogs
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