Auris's tinnitus drug misses main goals in study; shares sink

(Reuters) - Auris Medical Holding AG said its experimental drug for acute inner ear tinnitus missed the main goals of a late-stage study, sending its shares down more than 40 percent in premarket trading.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news

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Condition:   Tinnitus Intervention:   Other: Physical Therapy Sponsor:   VA Office of Research and Development Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conclusion: Round window niche drilling increases the contact area and time of methylprednisolone. It is an effective and safe salvage therapy of idiopathic SSNHL and its induced tinnitus.Audiol Neurotol 2018;23:309 –315
Source: Audiology and Neurotology - Category: Audiology Source Type: research
Purpose of review Recent enthusiasm for cannabinoid drugs for the treatment of chronic pain and some forms of epilepsy, raises the question of whether they could be useful for other disorders associated with abnormal neuronal activity in the brain, such as subjective tinnitus. Indeed, there is evidence to indicate that some tinnitus sufferers self-medicate using Cannabis. The aim of this review is to critically evaluate the available evidence relating to the effects of cannabinoids on tinnitus. Recent findings Despite the fact that cannabinoids have been shown to decrease neuronal hyperactivity in many parts of the br...
Source: Current Opinion in Neurology - Category: Neurology Tags: NEURO-OTOLOGY: Edited by Thomas Brandt Source Type: research
We report the case of a 42-year-old patient referred for suspicion of fibromuscular dysplasia in the context of a carotid artery dissection occurring after a minor trauma. Initial complaints included left hemicrania, lateral diplopia with left 6th cranial nerve palsy and pulsatile tinnitus. The work-up disclosed a large left carotid-cavernous fistula, as well as more proximal carotid lesions compatible with multifocal fibromuscular dysplasia. Personal history included colonic and uterine perforation. Family history disclosed a fatal hemorrhage due to rupture of a splenic artery aneurysm in the father and an iliac dissectio...
Source: Blood Pressure - Category: Hematology Tags: Blood Press Source Type: research
Discussion: Our review has not identified any reliable or reproducible objective measures of tinnitus. However, this piece of work has highlighted emerging areas where further high quality research may lead to the development of an effective method for objectively identifying and measuring the severity of tinnitus.
Source: Otology and Neurotology - Category: ENT & OMF Tags: REVIEW ARTICLES Source Type: research
Conclusions: Transtympanic resurfacing with bone cement, reinforcing the dehiscent JB to reduce focal turbulent flow, is a simple and effective surgical treatment option in patients with PT due to HJBD. In patients with HJBD, the objective measurement of PT by TSR/STA may be of help in selecting appropriate surgical candidates and objective evaluation of the treatment outcome.
Source: Otology and Neurotology - Category: ENT & OMF Tags: MIDDLE EAR AND MASTOID DISEASE Source Type: research
Conclusions: Daily portable audiometry is feasible in patients with MD. Future studies are planned to further analyze hearing fluctuations in MD with respect to frequencies affected, relationship to vertigo attacks, and response to treatments. Understanding hearing fluctuations in MD may aid refinement of diagnostic criteria and improve prognostication for long-term hearing loss, with a goal of informing treatments that might improve final hearing outcome.
Source: Otology and Neurotology - Category: ENT & OMF Tags: VESTIBULAR DISORDERS Source Type: research
Objective: Characterize the morbidity associated with vestibular schwannoma (VS) as documented by treating providers. Study Design: Retrospective analysis of the MarketScan database. Setting: MarketScan database. Subjects and Methods: A study of morbidity in VS patients who underwent treatment between 2002 and 2012 was conducted. A detailed account of morbidity at multiple time points before and after treatment was described. Results: Of 3,355 patients treated for VS, 2,029 (60.5%) underwent surgery and 1,326 (39.5%) radiation. The average (SD) age of diagnosis was 52.5 (12.1) years. Patients were followed fo...
Source: Otology and Neurotology - Category: ENT & OMF Tags: VESTIBULAR DISORDERS Source Type: research
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Source: International Journal of Audiology - Category: Audiology Authors: Source Type: research
The objective is to evaluate whether the bimodal therapy TRT and EMDR can provide faster and/or more relief from the annoyance experienced in chronic tinnitus patients ’ daily lives compared to the bimodal therapy TRT and CBT.So far there has been no prospective, randomized controlled, clinical trial with blind evaluator that compares CBT and EMDR as a treatment for tinnitus.Trial registrationClinicalTrials.gov, ID:NCT03114878. April 14, 2017.
Source: Trials - Category: Research Source Type: clinical trials
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