Limited Competition for Data Coordinating Center (DCC) for NIDDK Inflammatory Bowel Disease Genetics Consortium (IBDGC) (U24)

Funding Opportunity RFA-DK-16-510 from the NIH Guide for Grants and Contracts. The NIDDK Inflammatory Bowel Disease Genetics Consortium (IBDGC) was established in July, 2002 for the purpose of identifying genes predisposing to IBD. Since its establishment, the IBDGC, in collaboration with the International IBD Genetics Consortium, has identified about 200 such susceptibility loci. However, most of these loci include multiple genes, and for the great majority of the loci, specific casual genes and alleles have not yet been identified. The mechanisms by which the most of the causative genes influence IBD pathophysiology also remain unknown. The purpose of this FOA is to renew the IBDGC to identify risk-conferring and protective variants of causal genes for IBD, and to elucidate the mechanisms by which these variants influence the pathophysiology of IBD. The DCC will coordinate collaboration among the Genetic Research Centers (GRCs, described in the companion FOA RFA-DK-16-029), enrollment of subjects into the study, submission of blood and other biological samples to centralized repositories, processing of blood samples for extraction of DNA and isolation of cells and serum, submission of clinical, genetic, and molecular data to central databases, and analyses of data, and manage the operations of the Steering Committee and other operational committees. The DCC will also coordinate the development of pilot projects for rapid follow-up of emerging findings by members of the IBD...
Source: NIH Funding Opportunities (Notices, PA, RFA) - Category: Research Source Type: funding

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This article discusses how and when to diagnose Crohn disease with MRE (including discussion of the main differential diagnosis), how to describe the burden of enteric inflammation and its complications, and how to accurately classify disease based on interdisciplinary consensus. In addition, brief overviews of expected future MRE developments and alternative imaging modalities are also discussed.
Source: Magnetic Resonance Imaging Clinics of North America - Category: Radiology Authors: Source Type: research
PMID: 31735159 [PubMed - in process]
Source: Reviews on Recent Clinical Trials - Category: Cancer & Oncology Authors: Tags: Rev Recent Clin Trials Source Type: research
Authors: Dutzan N, Abusleme L Abstract T helper 17 (Th17) cells were first described as a T helper subset involved in the pathogenesis of experimental autoimmune inflammation. Since then, these cells have been described as orchestrators of immunopathology in several human inflammatory conditions including psoriasis, rheumatoid arthritis, and inflammatory bowel disease. More recently, the crucial role of Th17 cells in the regulation of immunity and protection of barrier sites has been unveiled. In the present work, we review the available evidence regarding Th17 cells in health and disease with a focus on the oral m...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
Authors: Tan P, Ye Y, Mao J, He L Abstract Autophagy is an intracellular degradation and recycling machinery by which cellular materials are delivered to the lysosome for disposal. Beyond lysosomal degradation, autophagy genes play additional roles in secretion and membrane-trafficking pathways. Ranging from cell-intrinsic and cell-type-specific regulation of innate inflammatory signaling pathways to intercellular cross talk through secretion of soluble factors (e.g., shaping the MHC immunopeptidome for T cell response, etc.), autophagy exerts multiple functions in driving inflammation and modulating the pathologic...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
Abstract Transmigration of neutrophils through an epithelial layer, such as in the intestine or lung, is a necessary response to a perceived attack at the mucosal surface of that tissue. This process is dynamically regulated by a number of interactive events between the neutrophil and other cell types and allows for an effective and localized neutrophil response. However, in certain inflammatory diseases, including inflammatory bowel disease and chronic obstructive pulmonary disease (COPD), persistent neutrophil accumulation can contribute to disease pathology. Elucidating the mechanisms of this aberrant neutrophi...
Source: Mol Biol Cell - Category: Molecular Biology Authors: Tags: Methods Mol Biol Source Type: research
 Have you ever wondered what it’s like to be an inpatient in a psych ward? In this two-part series, we go into detail about Gabe’s inpatient stay starting with the events that lead him to be an inpatient, and what his days were like after he was admitted. We talk about common misconceptions that you may have around what happens while you’re admitted, what your day looks like and who you’d spend time with. (Transcript Available Below) SUBSCRIBE &REVIEW About The Not Crazy Podcast Hosts Gabe Howard is an award-winning writer and speaker who lives with bipolar disorder. He is the author of t...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Bipolar Depression General Not Crazy Podcast Psychiatry Psychotherapy Suicide Treatment Source Type: blogs
Source: Clinical Gastroenterology and Hepatology - Category: Gastroenterology Authors: Source Type: research
AbstractPurpose of reviewThis review addresses our current knowledge of immune-mediated colitis (IMC) and offers a practical guide to its management.Recent findingsDue to the similarity in clinical, endoscopic, and histologic findings between IMC and inflammatory bowel disease (IBD), gastroenterologists have tailored their approach to IMC management to that of IBD.SummaryImmune checkpoint inhibitors (ICIs) are monoclonal antibodies that augment the T-cell anti-tumor response of the immune system and have demonstrated their importance in the treatment of a wide range of malignancies. With the growing benefits of ICIs, there...
Source: Current Treatment Options in Gastroenterology - Category: Gastroenterology Source Type: research
AbstractExperimental evidence “proves” that IL‐17 plays a critical role in the pathogenesis of inflammatory bowel disease, but blocking IL‐17 makes Crohn's disease worse.[1, 2] Only a subset of patients with melanoma benefit from checkpoint inhibitors[3] and only a subset of patients with any rheumatic disease benefit fr om a specific therapy. A scientist at the NIH using a rodent model can't replicate the experimental results of a scientist at Harvard. The intestinal microbiome might provide the explanation for each of these seemingly disparate conundrums.
Source: Arthritis and Rheumatology - Category: Rheumatology Authors: Tags: EDITORIAL Source Type: research
Publication date: Available online 16 November 2019Source: Redox BiologyAuthor(s): Solveigh C. Koeberle, André Gollowitzer, Jamila Laoukili, Onno Kranenburg, Oliver Werz, Andreas Koeberle, Anna P. KippAbstractGlutathione peroxidase 2 (GPx2) is one of the five selenoprotein GPxs having a selenocysteine in the active center. GPx2 is strongly expressed in the gastrointestinal epithelium, as is another isoform, GPx1, though with a different localization pattern. Both GPxs are redox-active enzymes that are important for the reduction of hydroperoxides.Studies on GPx2-deficient mice and human HT-29 cells with a stable k...
Source: Redox Biology - Category: Biology Source Type: research
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