Cooperative Ecosystem Studies Unit, Rocky Mountain CESU

Funding Opportunity Number: G14AS00049 Opportunity Category: DiscretionaryFunding Instrument Type: Cooperative AgreementCategory of Funding Activity: Science and Technology and other Research and DevelopmentCFDA Number: 15.808Eligible Applicants Others (see text field entitled "Additional Information on Eligibility" for clarification)Agency Name: DOI-USGS1Closing Date: Apr 11, 2014Award Ceiling: $0Expected Number of Awards: 1Creation Date: Apr 02, 2014Funding Opportunity Description: The US Geological Survey, Wyoming-Montana Water Science Center (WY-MT WSC), is offering a funding opportunity is to provide sample collection, analysis, and interpretation regarding the extraction of genetic information from sediment and water-column samples collected from approximately 12 sites on Lake Powell during two synoptic cruises, CY 2014 and 2015. This work is being done in support of a USGS funded project on mercury cycling in Lake Powell. Specifically, sediment and water column samples will be collected concomitant with those collected for geochemical analyses using sterile techniques. Total nucleic acids will be extracted using a combined physical and chemical lysis method. A set of broad and targeted primer sets will be used to assess the biodiversity of the microbial communities thought to participate in Hg(II-)-methylation. Community biodiversity will be assessed by subjecting genomic DNA to polymerase chain reaction (PCR) using universal primers targetin...
Source: Grants.gov - Category: Research Tags: Science and Technology and other Research and Development Source Type: funding

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Publication date: Available online 20 January 2020Source: Molecular and Cellular EndocrinologyAuthor(s): Ronald J. van der Sluis, Menno HoekstraAbstractAdrenal-derived glucocorticoids mediate the physiological response to stress. Chronic disturbances in glucocorticoid homeostasis, i.e. in Addison's and Cushing's disease patients, predispose to the development of atherosclerotic cardiovascular disease. Here we review preclinical and clinical findings regarding the relation between changes in plasma glucocorticoid levels and the atherosclerosis extent. It appears that, although the altered glucocorticoid function can in most...
Source: Molecular and Cellular Endocrinology - Category: Endocrinology Source Type: research
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Source: Gynecological Endocrinology - Category: Endocrinology Authors: Source Type: research
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Source: Gynecological Endocrinology - Category: Endocrinology Authors: Source Type: research
Publication date: Available online 20 January 2020Source: Journal of Pharmaceutical and Biomedical AnalysisAuthor(s): Alexandre Goyon, Peter Yehl, Kelly ZhangABSTRACTMarketed therapies in the pharmaceutical landscape are rapidly evolving and getting more diverse. Small molecule medicines have dominated in the past while antibodies have grown dramatically in recent years. However, the failure of traditional small and large molecules in accessing certain targets has led to increased R&D efforts to develop alternative modalities. Therapeutic oligonucleotides (ONs) can accurately be directed against their ribonucleic acid (RNA...
Source: Journal of Pharmaceutical and Biomedical Analysis - Category: Drugs & Pharmacology Source Type: research
ConclusionsThese results demonstrate that a novel proton-coupled organic cation antiporter plays a predominant role in the blood to brain influx of AC, MA and HA at the BBB, and thus affect the safety of Aconitum species.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
This study investigated the cardioprotective effect of vitexin against MIRI and its possible mechanism. Isolated SD rat hearts were subjected to MIRI in a Langendorff perfusion system, and H9c2 cells were subjected to hypoxia/reoxygenation (H/R) in vitro. Ex vivo experiments showed improved left ventricular function and reduced infarct size in the vitexin group. Transmission electron microscopy showed that I/R caused outer mitochondrial membrane rupture, cristae disappearance and vacuolation, while vitexin reduced mitochondrial damage and ultimately reduced cardiomyocyte apoptosis. In vitro, vitexin protected H9c2 cells fr...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
ConclusionsOur study demonstrates the antitumor effect of IL-24 on endometrial cancer and shows that IL-24 may be a promising therapeutic gene for endometrial cancer gene therapy.Graphical abstract
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Source: Core Evidence - Category: Drugs & Pharmacology Tags: Core Evidence Source Type: research
Contributors : Diane M Ward ; Alexandra SeguinSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusHepatocyte-specific loss of Slc25a37 (Mitoferrin1) in Mitoferrin2-/- mice did not affect animal viability or liver size suggesting that there must be alternative hepatocyte mitochondrial iron importers that function in the absence of Mitoferrins.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
This study aimed to explore the link between block copolymers’ interfacial properties and nanoscale carrier formation and found out the influence of length ratio on these characters to optimize drug delivery system. A library of diblock copolymers of PEG-PCL and triblock copolymers with additional PEI (PEG-PCL-PEI) were synthesized. Subsequently, a systematic isothermal investigation was performed to explore molecular arrangements of copolymers at air/water interface. Then, structural properties and drug encapsulation in self-assembly were investigated with DLS, SLS and TEM. We found the additional hydrogen bond in t...
Source: Acta Pharmaceutica Sinica B - Category: Cancer & Oncology Source Type: research
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