Evaluation of the Deleterious Health Effects of Consumption of Repeatedly Heated Vegetable Oil

Publication date: Available online 16 August 2016 Source:Toxicology Reports Author(s): Rekhadevi Perumalla Venkata, Rajagopal Subramanyam Consumption of repeatedly heated cooking oil (RHCO) has been a regular practice without knowing the harmful effects of use. The present study is based on the hypothesis that, heating of edible oils to their boiling points results in the formation of free radicals that cause oxidative stress and induce damage at the cellular and molecular levels. Peroxide value of heated oil, histopathological alterations, antioxidant enzyme levels and blood biochemistry were determined in Wistar rats treated with the RHCO. RHCO revealed higher peroxide value in comparison to oil that has been unheated or singly heated. Histopathological observation depicted significant damage in jejunum, colon and liver of animals that received oil heated repeatedly for 3 times. The altered antioxidant status reflects an adaptive response to oxidative stress. Alteration in the levels of these enzymes might be due to the formation of reactive oxygen species (ROS) through auto oxidation or enzyme catalyzed oxidation of electrophilic components within RHCO. Analysis of blood samples revealed elevated levels of glucose, creatinine and cholesterol with declined levels of protein and albumin in repeatedly heated cooking oil group. Hematological parameters did not reveal any statistically significant difference between treated and control groups. Results of the present study conf...
Source: Toxicology Reports - Category: Toxicology Source Type: research

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This study determined, if increased intrauterine oxidative stress (IUOx) affects adiposity, glucose and cholesterol metabolism in adult Ldlr−/−xSod2+/+ offspring from crossing male Ldlr−/−xSod2+/+ mice with Ldlr−/−xSod2 ± dams (IUOx) or Ldlr−/−xSod2 ± males with Ldlr−/−xSod2+/+ dams (control). At 12 weeks of age mice received Western diet for an additional 12 weeks. Adult male IUOx offspring displayed lower body weight and reduced adiposity associated with improved glucose tolerance compared to controls. Reduced weight gain in IUO...
Source: Redox Biology - Category: Biology Source Type: research
In this study, we present an electrochemical method to detect SMEnzyme concentration that is more sensitive and much faster than currently available commercial assays. For detection and the amplification of the SMEnzyme signal, methylene blue (MB)-encapsulated sphingomyelin (SM)-based liposome with 50 % cholesterol was synthesized via sonication method. Then the target SMEnzyme causes the free release of the MB from the MB-liposome formulation which can be detected on GCE||Au-PAni/N,S-GQDs electrode, prepared via interfacial polymerization and then self-assembly approach. The change of SM to gel state bilayer with increasi...
Source: Sensors and Actuators B: Chemical - Category: Chemistry Source Type: research
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Source: Current Nutrition and Food Science - Category: Nutrition Source Type: research
Publication date: Available online 18 September 2019Source: Nutrition, Metabolism and Cardiovascular DiseasesAuthor(s): Shih-Wei Lai, Yu-Hung Kuo, Chia-Wei Fang, Kuan-Fu Liao
Source: Nutrition, Metabolism and Cardiovascular Diseases - Category: Nutrition Source Type: research
CONCLUSIONS Long-term HFD in mice resulted in left ventricular hypertrophy, interstitial fibrosis, dysregulation of RAS, and abnormal expression of ICD proteins compared with ND mice, but did not affect the distribution of cardiomyocyte ICD proteins. Long-term HFD resulted in cardiac remodeling and altered expression of ICD proteins through RAS activation. PMID: 31523052 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
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Source: Archives of Public Health - Category: International Medicine & Public Health Source Type: research
AbstractAimsTo observe the effects of saxagliptin on the expression of mitogen-activated protein kinase 38 (p38MAPK), nephrin and podocin in renal tissue in type 2 diabetic (T2DM) rats, and to explore the possible mechanism of its renal protection.MethodsForty-eight male Sprague –Dawley rats were used for the study and divided into four different groups: normal controls (Group NC), DM controls (Group DM), DM + glibenclamide (Group Su) and DM + saxagliptin (Group Sa). The day drug administration started was defined as week 0. After 12 weeks, hemoglobin A1c (HbA1c) , total cholesterol (...
Source: Acta Diabetologica - Category: Endocrinology Source Type: research
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Source: Health News - UPI.com - Category: Consumer Health News Source Type: news
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Source: Medscape Cardiology Headlines - Category: Cardiology Tags: Neurology & Neurosurgery News Source Type: news
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Source: Nutrition, Metabolism and Cardiovascular Diseases - Category: Nutrition Source Type: research
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