Non-Hodgkin's lymphoma and pre-existing conditions: spectrum, clinical characteristics and outcome in 213 children and adolescents.
Non-Hodgkin's lymphoma and pre-existing conditions: spectrum, clinical characteristics and outcome in 213 children and adolescents.
Haematologica. 2016 Aug 11;
Authors: Attarbaschi A, Carraro E, Abla O, Barzilai-Birenboim S, Bomken S, Brugieres L, Bubanska E, Burkhardt B, Chiang AK, Csoka M, Fedorova A, Jazbec J, Kabickova E, Krenova Z, Lazic J, Loeffen J, Mann G, Niggli F, Miakova N, Osumi T, Ronceray L, Uyttebroeck A, Williams D, Woessmann W, Wrobel G, Pillon M
Abstract
Children and adolescents with pre-existing conditions such as DNA repair defects or other primary immunodeficiencies have an increased risk of non-Hodgkin's lymphoma. However, large-scale data on patients with non-Hodgkin's lymphoma and their entire spectrum of pre-existing conditions are scarce. In a retrospective multi-national study performed by means of questionnaires sent out to the national study groups or centres, the two largest consortia in childhood non-Hodgkin's lymphoma, the European Intergroup for Childhood non-Hodgkin's lymphoma and the international Berlin-Frankfurt-Munster Study Group, identified 213 patients with non-Hodgkin's lymphoma and a pre-existing condition. Four subcategories were established: a) cancer predisposition syndromes (n=124; 58%), b) primary immunodeficiencies not further specified (n=27; 13%), c) genetic diseases with no increased cancer risk (n=40; 19%), and d) non-classifiable conditions (n=22; 10%). Seventy-nine/124 (64%) canc...
Source: Haematologica - Category: Hematology Authors: Attarbaschi A, Carraro E, Abla O, Barzilai-Birenboim S, Bomken S, Brugieres L, Bubanska E, Burkhardt B, Chiang AK, Csoka M, Fedorova A, Jazbec J, Kabickova E, Krenova Z, Lazic J, Loeffen J, Mann G, Niggli F, Miakova N, Osumi T, Ronceray L, Uyttebroeck A, Tags: Haematologica Source Type: research
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