Sharing Mayo Clinic: Double Lung Transplant Recipient Beats Cystic Fibrosis

When Tammy Bolerjack was diagnosed with cystic fibrosis at age 18, she found herself frequently in and out of hospitals for treatments to help her breathe. Running 5K races and half-marathons certainly wasn ’t something she envisioned in her future. Little did she know then that eventually a double lung transplant at Mayo Clinic'sFlorida campus would not [...]
Source: News from Mayo Clinic - Category: Databases & Libraries Source Type: news

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Publication date: January 2019Source: The Annals of Thoracic Surgery, Volume 107, Issue 1Author(s): Sarah Cullivan, Karen Redmond, Carole Ridge, Oisin J. O’ConnellA 21-year-old patient presented with a short history of fatigue and dyspnea on a background of double-lung transplantation for cystic fibrosis and preexisting chronic superior vena cava obstruction. Computed tomography of the chest demonstrated a 3-cm mass occluding the right pulmonary veins, with associated right upper and lower lobe pulmonary parenchymal infiltrates. Two invasive procedures were performed, with similar complications in both procedures.
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Christina VanDerVelden, 17, of Jacksonville, Florida, slipped into a week-long coma after her healthy rapidly declined. The cystic fibrosis sufferer now needs a double lung transplant to survive.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
ABSTRACT The study of the human microbiome-and, more recently, that of the respiratory system-by means of sophisticated molecular biology techniques, has revealed the immense diversity of microbial colonization in humans, in human health, and in various diseases. Apparently, contrary to what has been believed, there can be nonpathogenic colonization of the lungs by microorganisms such as bacteria, fungi, and viruses. Although this physiological lung microbiome presents low colony density, it presents high diversity. However, some pathological conditions lead to a loss of that diversity, with increasing concentrations of so...
Source: Jornal Brasileiro de Pneumologia - Category: Respiratory Medicine Source Type: research
Authors: Regard L, Martin C, Chassagnon G, Burgel PR Abstract Introduction Cystic fibrosis (CF) is a genetic disease that primarily affects the respiratory system and often leads to respiratory failure and premature death. Although pulmonary complications contribute to 85% of deaths, non-pulmonary complications are responsible for significant morbidity and mortality in adults with CF. Areas covered This review summarizes acute and chronic non-pulmonary complications in CF patients, with emphasis on emerging complications and in the context of the current growth and ageing of the CF adult population. It also address...
Source: Expert Review of Respiratory Medicine - Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research
Conclusion: As for cardiac or hepatic transplantations, despite a strong immunosuppressive regimen, a high frequency of transient PF4/H Ab is observed in patients undergoing BLT. Their appareance is not related to thrombocytopenia and/or thrombotic events. However, they could be an early marker of a cellular reaction againts the graft.DisclosuresNo relevant conflicts of interest to declare.
Source: Blood - Category: Hematology Authors: Tags: 311. Disorders of Platelet Number or Function: Poster II Source Type: research
Conference abstracts
Source: The Aspergillus Website - updates - Category: Respiratory Medicine Authors: Source Type: news
Conclusion: There was 100% survival with all patients being discharged home within an average of 20.5 days post Tx. 100% were mobilised with physiotherapists within 12 hours of extubation, with an average increase in 6MWT on discharge of 360 mtrs. No patients required 02 therapy on discharge from MMUH.References:www.cfireland.ie/about-cf/living-with-cf (19.02.2108)Hirche et al., 2014 ‘Practice Guidelines: Lung Transplantatation in Patients with Cystic Fibrosis’ Pulm Med:621342
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Cystic fibrosis Source Type: research
Conclusion: We identified production of IL-17A among populations of ILCs, gamma delta T cells and iNKT cells in different lung disease entities which suggests that these cell populations can contribute to IL-17A-dependent pathologies in end stage lung disease.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Allergy and immunology Source Type: research
Background: 2017 NICE guidelines recommend use of a mucoactive agent [DNase, Mannitol, Hypertonic Saline] in patients with Cystic Fibrosis (CF) who have ‘clinical evidence of lung disease’ although a formal definition is not described. We speculated patients at our centre may have lung disease and not be treated according to guidelines.Aims: To use a pragmatic definition of ‘clinical evidence of lung disease’ to identify a patient cohort and assess NICE guideline adherence.Methods: Definition of lung disease used:·FEV1
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Cystic fibrosis Source Type: research
Conclusion: Improvement of FEV1 one year after LT was lower in CF patients with preoperative chronic Bcc infection and severe surgical complications, and at a longer length of stay in hospital during a year after LT.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Respiratory function technologists/scient Source Type: research
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