Vascularized Composite Allotransplantation: Medical Complications

The objective of this review is to summarize the collective knowledge regarding the risks and complications in vascularized composite tissue allotransplantation (VCA), focusing on upper extremity and facial transplantation. The field of VCA has entered its second decade with an increasing experience in both the impressive good outcomes, as well as defining challenges, risks, and experienced poor results. The limited and selective publishing of negative outcomes in this relatively new field makes it difficult to conclusively evaluate outcomes of graft and patient survival and morbidities. Therefore, published data, conference proceedings, and communications were summarized in an attempt to provide a current outline of complications. These data on the medical complications of VCA should allow for precautions to avoid poor outcomes, data to better provide informed consent to potential recipients, and result in improvements in graft and patient outcomes as VCA finds a place as a therapeutic option for selected patients.
Source: Current Transplantation Reports - Category: Transplant Surgery Source Type: research

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Source: St. Michael's Hospital News and Media - Category: Hospital Management Tags: Hospital News Source Type: news
Clinical Pathologic Mismatch in a TNF-α Inhibitor-Associated Drug Reaction J Drugs Dermatol. 2019 Aug 01;18(8):828-830 Authors: O’Brien KF, Maiman RE, DeWitt CA Abstract A 56-year-old Caucasian male with a history of chronic plaque psoriasis, primary sclerosing cholangitis status-post liver transplant on tacrolimus, and ulcerative colitis on infliximab developed a progressive erythematous eruption with associated fatigue, anorexia, myalgias, and arthralgias. On two separate occasions, his skin biopsy demonstrated a lichenoid interface dermatitis (LID). Despite multiple courses of oral predn...
Source: Journal of Drugs in Dermatology - Category: Dermatology Tags: J Drugs Dermatol Source Type: research
Publication date: 2019Source: Advances in Virus Research, Volume 104Author(s): Mitsuhiro Nishimura, Yasuko MoriAbstractIn this chapter, we present an overview on betaherpesvirus entry, with a focus on human cytomegalovirus, human herpesvirus 6A and human herpesvirus 6B. Human cytomegalovirus (HCMV) is a complex human pathogen with a genome of 235 kb encoding more than 200 genes. It infects a broad range of cell types by switching its viral ligand on the virion, using the trimer gH/gL/gO for infection of fibroblasts and the pentamer gH/gL/UL128/UL130/UL131 for infection of other cells such as epithelial and endothelial...
Source: Advances in Virus Research - Category: Virology Source Type: research
DiscussionWe suggest an open gastrectomy with roux-en-Y anastomosis as an alternative to the Nissen fundoplication for patients with connective tissue disease that develop terminal pulmonary consequences and require a lung transplant.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
Condition:   Bronchopulmonary Dysplasia Intervention:   Combination Product: stem cell transplantation Sponsor:   Vinmec Research Institute of Stem Cell and Gene Technology Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   aGVHD;   Stem Cell Transplant Complications Interventions:   Drug: Ruxolitinib;   Drug: Corticosteroid Sponsor:   Chinese PLA General Hospital Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
A Nova Scotian woman is celebrating her second chance at life after nearly choosing to die because of money. Natalie Jarvis received a double lung transplant in April.
Source: CBC | Health - Category: Consumer Health News Tags: News/Canada/Nova Scotia Source Type: news
This study found that liver transplant patients are at high risk of developing cardiovascular events post transplantation, even with no pre-existing risk factors. Can predictors be determined?Liver International
Source: Medscape Transplantation Headlines - Category: Transplant Surgery Tags: Transplantation Journal Article Source Type: news
ConclusionsAbdominal wall defects from resection of cancerous masses of the abdominal wall can be closed with a contralateral rectus abdominis muscle transplant in the absence of mesh.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
AbstractSevere combined immune deficiency (SCID) is caused by an array of genetic disorders resulting in a diminished adaptive immune system due to impaired T lymphocytes. In these patients, active infection at the time of hematopoietic transplantation has been shown to increase morbidity and mortality. To prevent transmission of infections in SCID patients, standardized infection control precautions should be implemented. An online survey regarding SCID-specific protocols was distributed through several immunodeficiency organizations. Seventy-three responses were obtained, with the majority (55%) of responses from the USA...
Source: Journal of Clinical Immunology - Category: Allergy & Immunology Source Type: research
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