In vitro Repression of Cyclooxygenase, Acetylcholinesterase Activities and Bacterial Growth by Trans-phytol and a Glycolipid from the Leaves of Homalomena sagittifolia

Conclusion: These results indicated the potential pharmacological properties of the leaves of H. sagittifolia and supported the traditional uses of the plant. Further studies are needed to understand its molecular interactions. This may lead to the development of standardized crude drugs and/or nutraceutical agents.
Source: Research Journal of Medicinal Plant - Category: Complementary Medicine Source Type: research

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Source: BMJ Comments - Category: General Medicine Source Type: forums
ConclusionsPresent study suggests that emergence of mutant P. jirovecii genotype are probably associated with drug resistance and mortality. Our data also suggest that DHPS mutational analyses should be performed in HIV-seropositive patients to avoid treatment failure and death due to PCP. However, role of underlying disease severity and comorbidities cannot be underestimated.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
More than 3 million cases of pneumonia occur annually in the United States. Defined as an infection of the lung, pneumonia can be bacterial, viral, of fungal in origin. The infection is usually further categorized into community-acquired pneumonia or hospital- or healthcare-acquired pneumonia.
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Resource Center Source Type: news
Authors: Fujishima N, Komiya K, Matsunaga N, Usagawa Y, Yamasue M, Hashinaga K, Umeki K, Nureki SI, Ando M, Matsunaga T, Kadota JI Abstract Tosufloxacin, which is not used to treat Mycobacterium tuberculosis, is a fluoroquinolone recommended for pneumonia when the possibility of tuberculosis infection cannot be excluded. In the present case, symptoms and chest infiltrative shadow initially improved by tosufloxacin. Therefore, we regarded this patient as having general pneumonia and did not perform follow-up chest X-ray until the infiltrates had completely disappeared. However, a few weeks later, the symptoms and th...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
Conclusions: Functional limitations at discharge from home health are associated with increased risk for potentially preventable readmissions. Future research is needed to determine whether improving functional independence decreases the risk for potentially preventable readmissions following home health care.
Source: Medical Care - Category: Health Management Tags: Original Articles Source Type: research
CONCLUSION: Results are still pending regarding the efficacy and any possible advantages of these new molecules, and also the emergence of drug resistant bacteria. Although these drugs share some advantages, they should not be selected over antibiotics usually prescribed for the treatment of CAP. PMID: 30638789 [PubMed - as supplied by publisher]
Source: Revue des Maladies Respiratoires - Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research
Chan Kwok-Yung Yuen Lipids play numerous indispensable cellular functions and are involved in multiple steps in the replication cycle of viruses. Infections by human-pathogenic coronaviruses result in diverse clinical outcomes, ranging from self-limiting flu-like symptoms to severe pneumonia with extrapulmonary manifestations. Understanding how cellular lipids may modulate the pathogenicity of human-pathogenic coronaviruses remains poor. To this end, we utilized the human coronavirus 229E (HCoV-229E) as a model coronavirus to comprehensively characterize the host cell lipid response upon coronavirus infection with an...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
In an effort to increase the value of care, the US Centers for Medicare and Medicaid Services (CMS) committed to changing 50% of its Medicare reimbursement to alternative payment plans by 2018. One strategy included the introduction of outcome-based pay-for-performance. As of fiscal year 2018 (October 2017), the approach included metrics for complications and mortality (Hospital Value-Based Purchasing Program and Hospital Acquired Condition Reduction Program) and readmissions (Hospital Readmissions Reduction Program [HRRP]). Within the HRRP, payments to hospitals are determined based on performance on 6 condition-specific ...
Source: JAMA Surgery - Category: Sports Medicine Source Type: research
ConclusionsThe rate of nosocomial cases was high despite established precaution measures.RSV was associated with morbidity and mortality comparable to influenza. Pneumonia remains the main complication of acute viral respiratory infections, and antimicrobial treatment should include both antiviral as well as antibacterial agents.
Source: Infection - Category: Infectious Diseases Source Type: research
Authors: Gavrilovic S, Andrijevic A, Mujakovic A, Odeyemi Y, Paralija B, Gajic O Abstract Pneumonia is the leading infectious cause of death worldwide. While inflammation is critically important in host response to microbial invasion, exaggerated inflammation can damage the lungs, contributing to respiratory failure and mortality. Corticosteroids are effective in reducing inflammation and can also cause immune suppression. Presently, clinicians are unable to reliably distinguish between exaggerated and appropriate immune response and thus cannot rapidly identify patients most likely to benefit from adjunctive corti...
Source: Bosnian Journal of Basic Medical Sciences - Category: General Medicine Tags: Bosn J Basic Med Sci Source Type: research
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