In vitro Repression of Cyclooxygenase, Acetylcholinesterase Activities and Bacterial Growth by Trans-phytol and a Glycolipid from the Leaves of Homalomena sagittifolia

Conclusion: These results indicated the potential pharmacological properties of the leaves of H. sagittifolia and supported the traditional uses of the plant. Further studies are needed to understand its molecular interactions. This may lead to the development of standardized crude drugs and/or nutraceutical agents.
Source: Research Journal of Medicinal Plant - Category: Complementary Medicine Source Type: research

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Publication date: Available online 19 October 2018Source: Parasitology InternationalAuthor(s): Maki Nishimura, Takashi Goyama, Sohei Tomikawa, Ragab M. Fereig, El-Sayed N. El-Alfy, Kisaburo Nagamune, Yoshiyasu Kobayashi, Yoshifumi NishikawaAbstractToxoplasma gondii is a protozoan parasite that causes fatal disease in New World monkeys. Several reports have described outbreaks of toxoplasmosis in squirrel monkeys. Here, we report the death of four squirrel monkeys in a captive colony from acute toxoplasmosis, one of which developed toxoplasmosis about 1 year after the initial outbreak. Serum anti–T. gondii antibody ...
Source: Parasitology International - Category: Parasitology Source Type: research
AbstractPurposeHospital-acquired bacterial pneumonia (HABP) is a critical concern in hospitals with ventilator-associated bacterial pneumonia (VABP) remaining the most common infection in the ICU, often due toStaphylococcus aureus, an increasingly difficult to treat pathogen. Anti-infective monoclonal antibodies (mAb) may provide new, promising treatment options. This randomized, double-blinded, placebo-controlled study aimed at assessing the safety and pharmacokinetics of AR-301, anS. aureus alpha toxin-neutralizing mAb, and exploring its clinical and microbiologic outcomes when used adjunctively with standard-of-care ant...
Source: Intensive Care Medicine - Category: Intensive Care Source Type: research
We describe the impact of a multifaceted program for decreasing ventilator-associated pneumonia (VAP) after implementing nine preventive measures, including selective oropharyngeal decontamination (SOD).MethodsWe compared VAP rates during an 8-month pre-intervention period, a 12-month intervention period, and an 11-month post-intervention period in a cohort of patients who received mechanical ventilation (MV) for  >  48 h. The primary objective was to assess the effect on first VAP occurrence, using a Cox cause-specific proportional hazards model. Secondary objectives included the impact on emergence ...
Source: Intensive Care Medicine - Category: Intensive Care Source Type: research
ConclusionsNIV showed a significant protective effect for intubation in immunosuppressed patients (cancer and transplants) and in patients with APE/CAP. However, the benefits of NIV for other etiologies are not clear and more trials are needed to prove these effects.
Source: Journal of Critical Care - Category: Gastroenterology Source Type: research
Authors: Liu GB, Cui XQ, Wang ZB, Wen L, Duan HL Abstract Sepsis, a systemic inflammatory response syndrome induced by infection, has high rates of morbidity and mortality. Pneumonia is a major cause for sepsis; however, pneumonia complicated by sepsis is a difficult clinical diagnosis. To assess the clinical relevance of serum procalcitonin (PCT) and hypersensitive C-reactive protein (hs-CRP) in early diagnosis of pneumonia complicated by sepsis, 220 patients with pneumonia who were admitted to hospital from July 2015 to July 2016 were enrolled in this study. The patients were divided into non-sepsis (N=82), mild ...
Source: Journal of Biological Regulators and Homeostatic Agents - Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research
Authors: Matsumoto H, Sato S, Fujita Y, Yashiro-Furuya M, Matsuoka N, Asano T, Kobayashi H, Watanabe H, Migita K Abstract Anti-melanoma differentiation-associated gene 5 (MDA5) antibodies are frequently detected in amyopathic dermatomyositis with rapidly progressive interstitial lung disease (RP-ILD). However, the presence of anti-MDA5 antibodies in other connective tissue diseases is not well known. We herein report a case of rheumatoid arthritis complicated with refractory anti-MDA5 antibody-positive ILD. A 75-year-old Japanese woman was referred to our hospital for refractory ILD. Serological testing was positiv...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
Authors: Takigawa Y, Fujiwara K, Saito T, Nakasuka T, Ozeki T, Okawa S, Takada K, Iwamoto Y, Kayatani H, Minami D, Sato K, Nagao M, Shibayama T Abstract A 66-year-old man was transferred to our hospital for pneumonia that was resistant to sulbactam/ampicillin and levofloxacin therapy. Chest computed tomography showed the rapidly progressive formation of multiple cavities. Methicillin-resistant Staphylococcus aureus (MRSA) was isolated, and the patient was diagnosed with necrotizing pneumonia caused by community-acquired MRSA (CA-MRSA). The MRSA strain had type IV staphylococcus cassette chromosome mec and genes enc...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
Determining prognosis in community acquired pneumonia (CAP), is very important. Many scores are introduced up to now for prediction of pneumonia prognosis like SMART-COP.
Source: The American Journal of Emergency Medicine - Category: Emergency Medicine Authors: Source Type: research
To derive a clinical prediction rule to predict pneumonia in patients with acute febrile respiratory illness to emergency departments.
Source: The American Journal of Emergency Medicine - Category: Emergency Medicine Authors: Source Type: research
Publication date: Available online 18 October 2018Source: The Lancet Respiratory MedicineAuthor(s): Samy Suissa, Sophie Dell'Aniello, Pierre ErnstSummaryBackgroundLong-acting β2 agonists (LABAs) and long-acting muscarinic antagonists (LAMAs) are the recommended initial maintenance treatment for chronic obstructive pulmonary disease (COPD), with almost all LABAs dispensed in fixed combination with inhaled corticosteroids (LABA-ICS). We compared the effectiveness and safety of LABA-ICS versus LAMA treatment initiation as a function of blood eosinophilia, a potential biomarker of ICS effectiveness, in a real-world settin...
Source: The Lancet Respiratory Medicine - Category: Respiratory Medicine Source Type: research
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