[CXCL13: a biomarker for acute Lyme neuroborreliosis : Investigation of the predictive value in the clinical routine.]

CONCLUSIONS: The biomarker CXCL13 has a higher sensitivity (100 % vs. 87 %) with a specificity (99 %) comparable with the established diagnostic markers for LNB, e.g. CSF pleocytosis and Borrelia-AI in the investigated patient population. The negative predictive value of CXCL13 is 100 %. Therefore, a normal CXCL13 level virtually excludes LNB. In the clinical routine CXCL13 is a valuable and practical diagnostic marker for LNB and can even detect an acute LNB in patients without CSF pleocytosis. PMID: 24682168 [PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/24682168?dopt=Abstract

Source: Der Nervenarzt - March 30, 2014 Category: Neurology Authors: Rupprecht TA, Lechner C, Tumani H, Fingerle V Tags: Nervenarzt Source Type: research