What Medical Problems Can Patients with Turner Syndrome Have?

Discussion Turner Syndrome (TS) is one of the most common genetic disorders in females. It was first described by Dr. Henry H. Turner in 1938. It affects 1 in 2000-2500 births and ~70,000 girls and women have TS in the United States. It is caused by the absence of all or part of the second X chromosome. The most common variation is 45X which affects about 50% of TS patients and usually has the most complications, but there are other variations. Phenotypes vary and therefore the age of diagnosis varies. Mean age of diagnosis unfortunately is 15 years. Diagnosis is made by chromosomal analysis. Haploinsufficiency of the SHOX gene is associated with short stature in Turner syndrome. Patient presentations depend on age and phenotype. Most (almost all) TS patients have short stature and primary ovarian failure, but patients can have a variety of medical problems. Patients need comprehensive management from a variety of specialists to address their medical and psychosocial needs throughout their lifetime. Recommendations for comprehensive management can be found in the To Learn More section below. Learning Point Medical problems that patients with Turner Syndrome can have include: *Short stature/growth retardation – almost 100% of patients Short stature occurs in almost all patients with an average of 8 in (20 cm) shorter than predicted mid-parental height. Final adult height has been dramatically improved with growth hormone treatment. Short stature or growth failure are ...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news

Related Links:

We present the case of a 56-year-old female presenting with bilateral foot pain. Imaging reveals symmetrical abductor digiti minimi atrophy associated with bilateral plantar fasciitis. These appearances are well demonstrated on both magnetic resonance imaging and ultrasound.
Source: The Journal of Foot and Ankle Surgery - Category: Orthopaedics Source Type: research
This study aimed to evaluate the therapeutic effect of folic acid (FA) on diabetic retinopathy (DR) in a genetic mouse model of obese type 2 diabetes mellitus (T2D). C57BL/KsJ-db/db(db/db) T2D mice were divided into control, FA, metformin (MET), and FA plus MET groups (n = 10/group). Serum levels of glucose, glycated hemoglobin, and insulin were determined weekly. The retinal thickness was measured using optical coherence tomography (OCT) at 4 weeks after treatments. The retinal expression and serum levels of vascular formation, inflammation, and oxidative stress-associated molecules were examined. Our results demonstrated...
Source: Ophthalmic Research - Category: Opthalmology Source Type: research
Conclusions: Eyes from diabetic patients in the initial stages of DR with different Early Treatment Diabetic Retinopathy Study gradings show similar prevalence of SCME and CIME, independent of the severity of the retinopathy. Retinal edema is located mainly in the INL and appears to be mostly extracellular except in the earliest stages of diabetic retinal disease where intracellular edema predominates.Ophthalmic Res
Source: Ophthalmic Research - Category: Opthalmology Source Type: research
Publication date: June 2019Source: Journal of Functional Foods, Volume 57Author(s): Han-Jun Kim, Eun-Ji Choi, Hyo Sung Kim, Chan-Woong Choi, Sik-Won Choi, Sun-Lim Kim, Woo-Duck Seo, Sun Hee DoAbstractPostmenopausal obesity is becoming a serious global health concern. Soyasaponin Ab (SA) inhibits adipocyte differentiation; however, the preventive and therapeutic potential of SA in postmenopausal obesity has not been clearly established. Here, we investigated the anti-obesity effects of SA in postmenopausal obesity in vitro and in vivo. SA inhibited adipocytic differentiation of 3T3-L1 cells and reduced lipid accumulati...
Source: Journal of Functional Foods - Category: Nutrition Source Type: research
Publication date: June 2019Source: Journal of Functional Foods, Volume 57Author(s): Kamesh Venkatakrishnan, Hui-Fang Chiu, Chin-Kun WangAbstractDiabetes mellitus (DM) and its related complications are the serious public health concern globally. This is the first review highlight on major functional foods and herbs with anti-diabetic activity particularly focus on type 2 diabetes mellitus (T2DM) with special reference to clinical trials and their proposed anti-diabetic mechanisms. This contribution summarizes the current prevalence of DM, etiology and pathophysiology, complications related to DM, current conventional treatm...
Source: Journal of Functional Foods - Category: Nutrition Source Type: research
Background: The circadian timing system or circadian clock plays a crucial role in many biological processes, such as the sleep-wake cycle, hormone secretion, cardiovascular health, glucose homeostasis, and body temperature regulation. Energy balance is also one of the most important cornerstones of metabolic processes, whereas energy imbalance is associated with many diseases (i.e., obesity, diabetes, cardiovascular disease). Circadian clock is the main regulator of metabolism, and this analysis provides an overview of the bidirectional effect of circadian rhythm on metabolic processes and energy balance.Summary: The circ...
Source: Annals of Nutrition and Metabolism - Category: Nutrition Source Type: research
This study briefly reviews the physiological mechanisms of exercise therapy in diabetes and the potential role of these cytokines in exercise.Key Messages: More high-quality, targeted, randomized controlled studies are needed urgently, from mechanism study to treatment direction, to provide a more theoretical basis for exercise therapy and to explore new therapeutic targets for diabetes.Ann Nutr Metab 2019;74:313 –321
Source: Annals of Nutrition and Metabolism - Category: Nutrition Source Type: research
Background: Health risks associated with the high consumption of sugar-sweetened beverages (SSBs) include overweight or obesity and their complications such as diabetes, as well as oral and dental decay, among others.Aim: The aim of the present statement is to inform health care professionals, parents, care-givers, teachers and school head teachers, stakeholders and governing bodies about the risks associated with drinking SSBs in infants, children and adolescents.Methods: We searched PubMed and the Cochrane databases for English language studies published from 2010 through October 1, 2018, for randomized clinical trials, ...
Source: Annals of Nutrition and Metabolism - Category: Nutrition Source Type: research
Authors: Tayal R, Hirst CS, Garg A, Kapur NK Abstract INTRODUCTION: Use of acute mechanical circulatory support (MCS) devices for high-risk cardiac intervention, cardiogenic shock, and advanced heart failure is growing. Alternate vascular access options for these devices remains a clinical challenge. Building on experience from trans-aortic valve replacement procedures, the axillary artery is becoming a common access route for acute MCS and represents an important advance in the development of acute MCS technologies. Areas covered: Authors review the clinical data and technical aspect of acute MCS deployment via th...
Source: Expert Review of Cardiovascular Therapy - Category: Cardiology Tags: Expert Rev Cardiovasc Ther Source Type: research
HIGH blood pressure risk could be lowered by making some diet or lifestyle changes. You could lower your risk of deadly hypertension symptoms and signs by regularly eating this breakfast. Are you at risk of high blood pressure?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
More News: ADHD | Anxiety | Back Curves | Celiac Disease | Child Development | Children | Classrooms | Coeliac Disease | Databases & Libraries | Diabetes | Eating Disorders & Weight Management | Education | Endocrinology | Gastroenterology | Genetics | Girls | Health | Hormones | Hospital Management | Hospitals | Hyperactivity | Hypertension | Hypothyroidism | Infertility | Internet | Klinefelter's Syndrome | Learning | Liver | Liver Disease | Lymphedema | Men | Obesity | Opthalmology | Orthopaedics | Osteoporosis | Otitis | Otitis Media | Ovaries | Pediatrics | Pregnancy | Primary Care | Psychiatry | Psychology | Reproduction Medicine | Scoliosis | Strabismus (squint) | Study | Teachers | Thyroid | Turner Syndrome | Ultrasound | Universities & Medical Training | Urinary Tract Infections | Urology & Nephrology | Women