Intratumoral interferon-gamma increases chemokine production but fails to increase T cell infiltration of human melanoma metastases

ConclusionThe melanoma vaccine induced circulating T cell responses, but it failed to infiltrate metastases, thus highlighting the need for combination strategies to support T cell infiltration. A single intratumoral injection of IFN γ induced T cell-attracting chemokines; however, it also induced secondary immune regulation that may paradoxically limit immune infiltration and effector functions. Alternate dosing strategies or additional combinatorial treatments may be needed to promote trafficking and retention of tumor-reacti ve T cells in melanoma metastases.
Source: Cancer Immunology, Immunotherapy - Category: Cancer & Oncology Source Type: research