Opportunities and challenges in incorporating ancillary studies into a cancer prevention randomized clinical trial

ConclusionsThe ancillary studies allowed study sites to broaden the research opportunities for their participants. Their implementation was efficient because of the established infrastructure of the primary trial. Implementation of these ancillary trials took substantial planning and coordination but enriched the overall primary trial.Trial registrationNCT00006392-S0000: Selenium and Vitamin E in Preventing Prostate Cancer (SELECT) (4 October 2000).NCT00780689-S0000A:   Prevention of Alzheimer’s Disease by Vitamin E and Selenium (PREADVISE) (25 June 2002).NCT00784225-S0000B: Vitamin E and/or Selenium in Preventing Cataract and Age-Related Macular Degeneration in Men on SELECT SWOG-S0000 (SEE) (31 October 2008).NCT00706121-S0000D: Effect of Vitamin E and/or Selenium on Colorectal Polyps in Men Enrolled on SELECT Trial SWOG-S0000 (ACP) (26 June 2008).NCT00063453-S0000C: Vitamin E and/or Selenium in Preventing Loss of Lung Function in Older Men Enrolled on SELECT Clinical Trial SWOG-S0000 (26 June 2003).
Source: Trials - Category: Research Source Type: clinical trials