Surgery Effective Against Immune Disorder That Weakens Muscles

Myasthenia gravis affects 60,000 Americans, but removal of thymus gland appears to help, research shows Source: HealthDay Related MedlinePlus Page: Myasthenia Gravis
Source: MedlinePlus Health News - Category: Consumer Health News Source Type: news

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Amifampridine tablets have receivedapproval for treating children aged 6 to 17 years who have Lambert-Eaton myasthenic syndrome (LEMS), a rare autoimmune disease that causes debilitating muscle weakness.
Source: JAMA - Category: General Medicine Source Type: research
Follicular dendritic cell sarcoma (FDCS) is a rare neoplasm that originates from follicular dendritic cells in lymphoid tissue while paraneoplastic pemphigus (PNP) is an autoimmune blistering disease associate...
Source: BMC Gastroenterology - Category: Gastroenterology Authors: Tags: Case report Source Type: research
Autoimmune encephalitis (AE) is a newly recognized autoimmune disorders in which the targets are proteins or receptors involved in synaptic transmission and neuronal excitability. α-amino-3-hydroxy-5-methyl-4-...
Source: BMC Neurology - Category: Neurology Authors: Tags: Case report Source Type: research
Authors: Jordan H, Ortiz N Abstract Myasthenia gravis is a neuroimmunological disorder leading to skeletal muscle weakness. Common symptoms of the disease, such as anxiety, depression, and insomnia, can cause significant distress in patients. Unfortunately, selecting an appropriate medication for treatment of psychiatric comorbidities can prove to be challenging for providers given the unique pharmacologic constraints that myasthenia gravis presents. The authors present the following clinical vignette and accompanying discussion in an attempt to highlight the special considerations that must be taken into account w...
Source: Journal of Neuropsychiatry and Clinical Neurosciences - Category: Psychiatry Tags: J Neuropsychiatry Clin Neurosci Source Type: research
The thymus is a dynamic organ that undergoes changes throughout life and can demonstrate a myriad of pathologic alterations. A number of benign entities of the thymus prove to be diagnostic dilemmas owing to their resemblance and association with true thymic tumors. These are usually discovered incidentally on routine imaging and most patients are either asymptomatic or present with signs and symptoms of compression of adjacent organs. The radiologic appearance of these lesions varies from simple cysts to complex masses that are suspicious for malignancy. The diagnosis is usually made purely on morphologic grounds, however...
Source: Advances in Anatomic Pathology - Category: Pathology Tags: Review Articles Source Type: research
This study of MG patients compared the effect of early and late extubation following thymectomy on clinical outcome.MethodsWe performed a study of data from 96 patients with MG who received thymectomy procedures, followed by early (  6 h) extubation, at our institution between October 2011 and November 2017. Patient clinical and demographic characteristics, preoperative data, and postoperative clinical outcomes were analyzed. Data sharing is not applicable to this article as no datasets were generated or analyzed during the current study.ResultsThe patients in the early extubation group (n = 53) a...
Source: Neurological Sciences - Category: Neurology Source Type: research
Condition:   Myasthenia Gravis Intervention:   Sponsors:   Charite University, Berlin, Germany;   NeuroCure Clinical Research Center, Charite, Berlin Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
After the publication of the original article [1], it came to the authors ’ attention that there was an error in the originally published version of Fig. 5b. The image of CD4+CD25+ T cells of the statin-Dex group ...
Source: Journal of Neuroinflammation - Category: Neurology Authors: Tags: Correction Source Type: research
Myasthenia Gravis is an autoimmune disorder in which antibodies develop against components of the post-synaptic neuromuscular junction membrane [1]. Patients present with skeletal muscle weakness involving extraocular, bulbar and appendicular muscles and, less commonly, the diaphragm. The two most common antigens are the acetylcholine receptor [2] in 85% of patients and muscle specific kinase [3 –6] in 10% of patients. Other newly discovered rarer antigens include low-density lipoprotein receptor-related protein 4 (Lrp4) [7–9] and agrin [10–12].
Source: Neuromuscular Disorders - Category: Neurology Authors: Source Type: research
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