Featured Review: Sun protection to prevent basal cell carcinoma and cutaneous squamous cell carcinoma of the skin
One randomised trial has been done to date that compares different ways of using sunscreen and physical barrier methods to protect against common non-melanoma skin cancers. The quality of evidence to date is low but the review team urge caution in changing behaviour on the basis of the review findings.Keratinocyte cancer is a more common but less serious type of skin cancer than melanoma. It comprises basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (cSCC). The main risk factor for keratinocyte cancer is exposure to ultraviolet radiation, which is a component of sunlight. The incidence of this type of cancer has increased since the 1960s and costs of treating it are high because as much as 95% skin cancers are of this type. Applying sunscreen and physical barrier methods, such as sun-protective clothing, hats, sunglasses, and avoiding direct exposure to sun by searching for shade when outdoors are often advised to stop this type of cancer from developing.A team of Cochrane authors based in Colombia and United Kingdom worked withCochrane Skin to investigate how different strategies such as topical sunscreen and physical barrier methods prevent the development of BCC and cSCC of the skin in adults and children, when compared with any type of control.One randomised controlled trial from Australia that evaluated two different strategies was found. In one of the groups people were instructed to apply sunscreen daily and in the other group they were instructe...
CONCLUSIONS: Dermatological follow-up is important in OTRs, due to the higher risk of tumors and mainly NMSC. Clinical and environmental factors, including cigarette smoking, are useful in characterizing OTR with higher risk of NMSC. PMID: 30251802 [PubMed - as supplied by publisher]
CONCLUSIONS: This study demonstrated the increased risk of skin cancer in transplant patients during the first 7 years of follow-up and made the dermatologists aware about the need of a regular cutaneous follow up for this subset of patients. PMID: 30229636 [PubMed - as supplied by publisher]
Cutaneous Squamous cell carcinoma (cSCC) is after basal cell carcinoma the second most common non-melanoma skin cancer and accounts for 20% of all cutaneous malignancies . Particularly effected are organ transplant recipients (OTRs) with a 65 to 250 higher risk than the general population due to their immunosuppression as major risk factor . Moreover, cSCC in OTRs are often quite aggressive with high recurrence rates, metastasis and death . The most widely used agents to prevent graft rejection in solid OTRs are calcineurin-inhibitors in combination with mycophenolate mofetil (MMF) and corticosteroids as the stand...
CONCLUSIONS: Liver transplant recipients are not at a lower risk of NMSC than RTR. Our study supports routine and regular post-transplant skin surveillance of all LTR, like other OTR. PMID: 29292515 [PubMed - as supplied by publisher]
Abstract: Background: Immunosuppressive therapy, which is necessary to avoid graft rejection in renal transplant recipients, presents an increased risk of several pathologies, namely infectious and neoplastic. Objectives: To identify the most frequent skin diseases and their clinical and demographical risk factors within a population of renal transplant recipients. Methods: A retrospective study of renal transplant recipients referred to dermatology visit and observed for the first time from January 2008 to December 2014. Results: The study included 197 patients, 120 men (60,9%). Mean age was 50,7 years ( ±13,4). 12...
We report the effect of P+SS, applied for 16 weeks, in a case series of 10 OTR subjects with multiple AK lesions. P+SS treatment was associated with a relevant AK lesion reduction (#x3e;75%) in 7 patients (with a complete clearance in 3 subjects) with an improvement in the field of cancerization. This medical device could be considered a promising long-term curative and preventive treatment in OTR patients at high risk of non-melanoma skin cancers.Case Rep Dermatol 2017;9:211 –216
Conclusion: Non-melanoma skin cancer was a common reason for dermatology consultation in Portuguese KTRs. It is imperative for KTRs to have access to specialized dermatology consultation for early referral and treatment of skin malignancies.
Conclusions De novo mTOR inhibition was associated with a substantially and significantly reduced risk of basal cell carcinoma of the skin after kidney transplantation. A significant reduction of the incidence of other cancers was not found.
CONCLUSIONS: A Phase 3 study is now warranted to assess the chemopreventive efficacy of nicotinamide in renal transplant recipients. This article is protected by copyright. All rights reserved. PMID: 27061568 [PubMed - as supplied by publisher]
CONCLUSION: Regular dermatological follow-up of RTRs can help to make earlier diagnoses, resulting in better quality of life and lower morbidity and mortality. PMID: 26185461 [PubMed]