Featured Review: Sun protection to prevent basal cell carcinoma and cutaneous squamous cell carcinoma of the skin

One randomised trial has been done to date that compares different ways of using sunscreen and physical barrier methods to protect against common non-melanoma skin cancers. The quality of evidence to date is low but the review team urge caution in changing behaviour on the basis of the review findings.Keratinocyte cancer is a more common but less serious type of skin cancer than melanoma. It comprises basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (cSCC). The main risk factor for keratinocyte cancer is exposure to ultraviolet radiation, which is a component of sunlight. The incidence of this type of cancer has increased since the 1960s and costs of treating it are high because as much as 95% skin cancers are of this type. Applying sunscreen and physical barrier methods, such as sun-protective clothing, hats, sunglasses, and avoiding direct exposure to sun by   searching for shade when outdoors are often advised to stop this type of cancer from developing.A team of Cochrane authors based in Colombia and United Kingdom worked withCochrane Skin to investigate how different strategies such as topical sunscreen and physical barrier methods prevent the development of BCC and cSCC of the skin in adults and children, when compared with any type of control.One randomised controlled trial from Australia that evaluated two different strategies was found. In one of the groups people were instructed to apply sunscreen daily and in the other group they were instructe...
Source: Cochrane News and Events - Category: Information Technology Authors: Source Type: news

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CONCLUSIONS: Liver transplant recipients are not at a lower risk of NMSC than RTR. Our study supports routine and regular post-transplant skin surveillance of all LTR, like other OTR. PMID: 29292515 [PubMed - as supplied by publisher]
Source: The Australasian Journal of Dermatology - Category: Dermatology Authors: Tags: Australas J Dermatol Source Type: research
Abstract: Background: Immunosuppressive therapy, which is necessary to avoid graft rejection in renal transplant recipients, presents an increased risk of several pathologies, namely infectious and neoplastic. Objectives: To identify the most frequent skin diseases and their clinical and demographical risk factors within a population of renal transplant recipients. Methods: A retrospective study of renal transplant recipients referred to dermatology visit and observed for the first time from January 2008 to December 2014. Results: The study included 197 patients, 120 men (60,9%). Mean age was 50,7 years ( ±13,4). 12...
Source: Anais Brasileiros de Dermatologia - Category: Dermatology Source Type: research
We report the effect of P+SS, applied for 16 weeks, in a case series of 10 OTR subjects with multiple AK lesions. P+SS treatment was associated with a relevant AK lesion reduction (#x3e;75%) in 7 patients (with a complete clearance in 3 subjects) with an improvement in the field of cancerization. This medical device could be considered a promising long-term curative and preventive treatment in OTR patients at high risk of non-melanoma skin cancers.Case Rep Dermatol 2017;9:211 –216
Source: Case Reports in Dermatology - Category: Dermatology Source Type: research
Conclusion: Non-melanoma skin cancer was a common reason for dermatology consultation in Portuguese KTRs. It is imperative for KTRs to have access to specialized dermatology consultation for early referral and treatment of skin malignancies.
Source: Anais Brasileiros de Dermatologia - Category: Dermatology Source Type: research
Conclusions De novo mTOR inhibition was associated with a substantially and significantly reduced risk of basal cell carcinoma of the skin after kidney transplantation. A significant reduction of the incidence of other cancers was not found.
Source: Nephrology Dialysis Transplantation - Category: Urology & Nephrology Authors: Tags: Renal Transplantation Source Type: research
CONCLUSIONS: A Phase 3 study is now warranted to assess the chemopreventive efficacy of nicotinamide in renal transplant recipients. This article is protected by copyright. All rights reserved. PMID: 27061568 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - Category: Dermatology Authors: Tags: Br J Dermatol Source Type: research
CONCLUSION: Regular dermatological follow-up of RTRs can help to make earlier diagnoses, resulting in better quality of life and lower morbidity and mortality. PMID: 26185461 [PubMed]
Source: Clinical, Cosmetic and Investigational Dermatology - Category: Dermatology Tags: Clin Cosmet Investig Dermatol Source Type: research
Authors: Secnikova Z, Gopfertova D, Hoskovac L, Hercogova J, Dzambova M, Jirakova A, Rajska L, Rob F, Smerhovsky Z Abstract AIMS: To perform the first study in Czech Republic on heart transplant recipients (HTRs), compare the risks for different types of cancer and provide comprehensive analysis of skin cancer and other types of cancer morbidity from which we would be able to derive an evidence-based skin cancer surveillance program. MATERIALS AND METHODS: A retrospective cohort study was performed to determine and compare standardized morbidity ratio (SMR) of different types of cancer developed after heart tra...
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - Category: Biomedical Science Tags: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Source Type: research
Abstract According to the European Union Tissues and Cells Directives donation of tissue is contraindicated in the presence of or a previous history of malignant disease, with the exception of cutaneous basal cell carcinoma. Skin cancer is the most common cancer. Due to ultraviolet light exposure and increasing life expectancy an increasing prevalence of malignant or premalignant skin lesions is observed, which may result in a decline of the availability of skin for transplantation. A risk assessment based on published studies and expert opinion was performed in order to investigate the risk of transmitting ma...
Source: Cell and Tissue Banking - Category: Stem Cells Source Type: research
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