Frozen Embryos May Increase Chances Of Becoming Pregnant

BOSTON (CBS) – Fertility experts usually prefer to work with fresh embryos when women are undergoing in vitro fertilization (IVF), but according to a new study frozen may be better than fresh in some women. About 10% of women of reproductive age have polycystic ovarian syndrome (PCOS). It’s a common cause of infertility and IVF in these women can pose some risks. But researchers looked at more than 1500 women with PCOS and found that those who received frozen embryos had lower rates of complication and a greater likelihood of a successful pregnancy than those who received fresh embryos. The scientists say fertility specialists should consider freezing all embryos women with PCOS before transferring them into the womb.
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health Local News Syndicated Local CBS Boston Dr. Mallika Marshall In Vitro Fertilization Source Type: news

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Publication date: Available online 14 December 2018Source: Reproductive BioMedicine OnlineAuthor(s): Nasim Tabibnejad, Mohammad Hasan Sheikhha, Nasrin Ghasemi, Fesahat, Mehrdad Soleimani, Abbas AflatoonianAbstractResearch questionCan a combination of time-lapse morphokinetic parameters and cumulus cell gene expression in polycystic ovary syndrome (PCOS) women be used to predict assisted reproductive treatment outcome?DesignA total of 547 embryos from 100 intracytoplasmic sperm injection (ICSI) cycles were evaluated. Fifty women with PCOS and 50 women who were categorized as tubal factor infertility were recruited. Time-lap...
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research
Polycystic ovary syndrome (PCOS) is a complex endocrine condition that represents a lifelong health concern for 1 in 10 women worldwide.1 PCOS is commonly diagnosed by the presence of ovulatory dysfunction, androgen excess, and/or ovaries with polycystic morphology on ultrasound examination.2 Half of patients experience overweight or obesity.3 Most are at increased risk for serious comorbidities, including infertility, pregnancy complications (eg, gestational diabetes mellitus), impaired glucose tolerance, insulin resistance, type 2 diabetes mellitus, cardiovascular disease, gynecological cancers, anxiety, depression, eati...
Source: Journal of the American Dietetic Association - Category: Nutrition Authors: Tags: Research Source Type: research
This study demonstrated that the efficacy of letrozole is not superior to the clomiphene in patients with PCOS.
Source: Medicine - Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
Abstract Polycystic ovary syndrome (PCOS) is the most common metabolic and endocrine disorder in women, leading to infertility. However, there is no general agreement concerning how to diagnose and treat PCOS. The Rotterdam consensus statement from the European Society of Human Reproduction and Embryology/American Society for Reproductive Medicine, the Chinese diagnostic criteria and consensus statement, and the clinical practice guideline from the Endocrine Society in the USA are widely recognized. Guidance has been provided for clinical practice based on a comparative analysis of the above three practice guideli...
Source: J Zhejiang Univ Sci ... - Category: Science Authors: Tags: J Zhejiang Univ Sci B Source Type: research
ConclusionIn women with PCOS undergoing stimulated IUI, CC, letrozole and gonadotropins were equally effective and safe. Since multi-follicular growth increased the multiple pregnancy rates without increasing the overall live birth rate, ovulation induction would strictly aim for mono-follicular growth. Since letrozole had the highest mono-follicular growth rate, we recommend this drug as the treatment of first choice in infertile women undergoing ovulation induction and IUI.
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
Vitamin D deficiency in women diagnosed with polycystic ovary syndrome (PCOS) remarkably decreases the chance of pregnancy, which might be related to its impact on metabolic abnormalities in these patients. It...
Source: Reproductive Biology and Endocrinology - Category: Endocrinology Authors: Tags: Research Source Type: research
CONCLUSION: Overall, the findings of this trial supported that 50,000 IU vitamin D supplementation every other week for 8 weeks had beneficial effects on insulin metabolism, and lipid profile of infertile women with PCOS who are candidate for IVF. These benefits might not be evident upon having sufficient vitamin D levels. TRIAL REGISTRATION: This study was retrospectively registered in the Iranian website ( www.irct.ir ) for clinical trials registration ( http://www.irct.ir : IRCT20170513033941N27). PMID: 30286768 [PubMed - in process]
Source: Reproductive Biology - Category: Reproduction Medicine Authors: Tags: Reprod Biol Endocrinol Source Type: research
CONCLUSION: In summary, Th1 and Th17 bias and reduction of Treg and Th2 cells as regulators of immune responses might be involved in the pathogenesis of PCOS. These results are suggestive of an altered immune response to inflammatory status in PCOS patients, likely causing some complications such as infertility in these patients. PMID: 30246693 [PubMed - in process]
Source: Iranian Journal of Immunology - Category: Allergy & Immunology Tags: Iran J Immunol Source Type: research
Publication date: Available online 13 September 2018Source: European Journal of Obstetrics &Gynecology and Reproductive BiologyAuthor(s): Tabibnejad N., Soleimani M., A. AflatoonianAbstractObjectivesOocyte parameters as well as embryo developmental kinetics can be applied as non-invasive predictors for selection of viable embryos and clinical outcomes. Time-lapse morphokinetic events in conjunction with zona pellucida birefringence (ZPB) and meiotic spindle visualization (MSV) have been evaluated for predicting pregnancy outcome.Study designWe assessed a total of 547 embryos from 100 intra cytoplasmic sperm injection c...
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
Abstract BACKGROUND: Letrozole is widely employed as ovulation induction agent in women with PCOS, but its use in mild stimulation (MS) protocols for IVF is limited. Aim of the present study was to evaluate the feasibility of a MS protocol with letrozole plus hMG in non-obese PCOS women undergoing IVF after a metformin pre-treatment. METHODS: We retrospectively evaluated the data of 125 non-obese PCOS undergoing MS with letrozole plus hMG, 150 IU as starting dose, (group 1, N = 80) compared to those undergoing a conventional IVF stimulation protocols (CS) (group 2, N = 45) pri...
Source: Reproductive Biology - Category: Reproduction Medicine Authors: Tags: Reprod Biol Endocrinol Source Type: research
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