Single-Center Series of Bone-Marrow Biopsy-Defined Large Granular Lymphocyte leukemia; high rates of sustained response to oral methotrexate

Conclusion. Single agent oral methotrexate appears to be highly efficacious, resulting in long response durations accompanied by minimal toxicity. Teaser 39 patients were stringently diagnosed with large granular lymphocyte leukemia. 15 (38%) remain untreated, 13/24 initially treated with prednisolone, overall response rate (ORR) 84.6%, median duration of response (DOR) 13.5 months, 9/24 received oral methotrexate ORR 89%, median DOR 132.7 months. Five received methotrexate following prednisolone failure; all responded. Single agent oral methotrexate results in long responses with minimal toxicity.
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research