Aberrant p15, p16, p53 and DAPK gene methylation in myelomagenesis: clinical and prognostic implications

Conclusion The current study supports a relevant role for p15, p16 and DAPK hypermethylation in the genesis of the plasma cell neoplasm. DAPK hypermethylation might also be an important step in the progression from MGUS to MM. Teaser Microabstract: Aberrant DNA methylation is important in multiple myeloma pathogenesis. Methylation of p15, p16, p53 and DAPK genes was evaluated in bone marrow (94 patients; 8 controls) by methylation-specific polymerase chain reaction. 63% of MM and 39% of MGUS presented ≥1 hypermethylated gene (p<0.05). This supports a relevant role for hypermethylation in the pathogenesis of the plasma cell neoplasms.
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research