Cutting off the cancer fuel supply

Research has identified a new approach to cancer therapy in cutting off a cancer cell ’s ‘fuel supply’ by targeting a cellular survival mechanism known as autophagy.
Source: ScienceDaily Headlines - Category: Science Source Type: news

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Jakob von Frieling, Christine Fink, Jacob Hamm, Kenneth Klischies, Michael Forster, Thomas C. G. Bosch, Thomas Roeder, Philip Rosenstiel, Felix Sommer
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Publication date: Available online 20 September 2018Source: Results in PhysicsAuthor(s): Limin Dong, Dongyue Liu, Xuejiao Li, Kejia Wu, Wanqi ZhangAbstractBiomass carbon quantum dots (CQDs) were widely used in bioimaging and WO2.72 has great potential in cancer therapy. The biomass CQDs were prepared by mixed acid oxidation method with biomass materials such as pods, tobacco leaves and cysteine as carbon sources. Properties of biomass carbon quantum dots were characterized, including micromorphology, the functional group composition, photoluminescence properties and fluorescence labeling ability in HepG2 cells. And the cyt...
Source: Results in Physics - Category: Physics Source Type: research
Authors: Zhang D, Dong Y, Zhao Y, Zhou C, Qian Y, Hegde ML, Wang H, Han S Abstract The use of plant‑based compounds derived from traditional medicine to improve human diseases has been gaining momentum, due to their high bioavailability and moderate adverse effects. Sinomenine is one such biomonomer alkali compound derived from Sinomenium acutum and is known for its anti‑inflammatory and antitumor effects. However, the molecular mechanism(s) of its antitumor properties are not fully characterized. In the present study, we evaluated the radiosensitizing effects of the water‑soluble sinomenine, sinomenine hydro...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Authors: Lopes-Souza P, Dionello CF, Sá-Caputo DDC, Moreira-Marconi E, Frederico EHFF, Marchon RM, Bergmann A, Furness T, Bernardo-Filho M Abstract The purpose of this systematic review was to investigate the effects of whole body vibration (WBV) exercise in the management of cancer therapy-related morbidities. The PubMED and PEDro databases were used to access publications published in English about the use of whole body vibration (WBV) exercises in cancer patients until February 22nd 2017. The studies included were classified according to the level of evidence (LE) by the National Health and Medical Resear...
Source: Drug Discoveries and Therapeutics - Category: Drugs & Pharmacology Tags: Drug Discov Ther Source Type: research
International Journal of Dermatology, EarlyView.
Source: International Journal of Dermatology - Category: Dermatology Authors: Source Type: research
Publication date: 1 January 2019Source: Materials Science and Engineering: C, Volume 94Author(s): Lijun You, Xiaocui Liu, Zhexiang Fang, Qianhui Xu, Qiqing ZhangAbstractA new folic acid (FA)-conjugated poly (lactic-co-glycolicacid) (PLGA)-polyethylene glycol (PEG) nano-noisome was prepared. The noisome was employed as a drug delivery system to load curcumin (Cur) as a model drug and fluorescent probe for cervical cancer therapy and cell imaging. The Fe3O4@PLGA-PEG@FA noisomes were prepared through facile emulsion solvent evaporation and conjugation chemistry method, possessing the properties of high rapid magnetic separati...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
Authors: Mukherjee A, Waters AK, Babic I, Nurmemmedov E, Glassy MC, Kesari S, Yenugonda VM Abstract Antibody drug conjugates (ADC's) represent a promising and an efficient strategy for targeted cancer therapy. Comprised of a monoclonal antibody, a cytotoxic drug, and a linker, ADC's offer tumor selectively, reduced toxicity, and improved stability in systemic circulation. Recent approvals of two ADC's have led to a resurgence in ADC research, with more than 60 ADC's under various stages of clinical development. The therapeutic success of future ADCs is dependent on adherence to key requirements of their design and ...
Source: Human Antibodies - Category: Biochemistry Tags: Hum Antibodies Source Type: research
Conclusion: Although, the advanced cancer therapeutics have been established but the combination of different strategies is very important. The efficiency of the treatments depends on the stage of cancer and response of patients. Search for closely defined and selective molecular targets for a particular therapy is very complicated due to heterogenic nature of tumor environment, different therapeutic agents, incubation time, exposure doses and selectivity of therapy. The most promising photodynamic therapy (PDT) and multi- targeted therapies are being established but the question whether the cellular proteins that are most...
Source: Current Signal Transduction Therapy - Category: Molecular Biology Source Type: research
Publication date: December 2018Source: Biomedicine &Pharmacotherapy, Volume 108Author(s): Charlette Tiloke, Krishnan Anand, Robert M. Gengan, Anil A. ChuturgoonAbstractCancer is classified as one of the leading causes of global mortality. It has affected millions of people, often with poor prognosis. Having severe side-effects with conventional chemotherapy, alternate drugs and therapies are actively being investigated. There is a need for innovative drug discovery and design as existing cancer therapies are costly and not readily available. Ayurveda and traditional medicine have utilised natural resources such as plan...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Jason Roszik, Kari L. Ring, Khalida M. Wani, Alexander J. Lazar, Anna V. Yemelyanova, Pamela T. Soliman, Michael Frumovitz, Amir A. Jazaeri
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
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