Early recognition of lung cancer in workers occupationally exposed to asbestos.

[Early recognition of lung cancer in workers occupationally exposed to asbestos]. Radiologe. 2016 Aug 8; Authors: Hofmann-Preiß K, Rehbock B Abstract Despite the fact that working with asbestos and placing it on the market have been banned in Germany since 1993 according to the Ordinance on Hazardous Substances, asbestos-related diseases of the lungs and pleura are still the leading cause of death in occupational diseases. The maximum industrial usage of asbestos was reached in former West Germany in the late 1970s and in former East Germany the late 1980s. Occupational diseases, mainly mesotheliomas and lung cancer emerging now are thus caused by asbestos exposure which occurred 30-40 years earlier. It is known that the combination of smoking and asbestos exposure results in a superadditive increase in the risk to develop lung cancer. No suitable screening methods for early detection of malignant mesothelioma are currently available and the therapeutic options are still very limited; however, the national lung screening trial (NLST) has shown for the first time that by employing low-dose computed tomography (LDCT) in heavy smokers, lung cancer mortality can be significantly reduced. According to current knowledge the resulting survival benefits far outweigh the potential risks involved in the diagnostic work-up of suspicious lesions. These results in association with the recommendations of international medical societies and organizations wer...
Source: Der Radiologe - Category: Radiology Authors: Tags: Radiologe Source Type: research

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Image-based response assessment is often used as a surrogate for the efficacy of a treatment in patients. The radiological response assessment in patients with malignant pleural mesothelioma (MPM) is notoriously difficult, despite changes in the scoring system, modified Response Evaluation Criteria in Solid Tumors (modified RECIST). The current clinical method for tumor response assessment in mesothelioma is the modified RECIST guideline, which calls for two linear measurements of tumor thickness to be summed from each of three axial sections, primarily in computed tomography (CT) scans.
Source: Lung Cancer - Category: Cancer & Oncology Authors: Source Type: research
Rationale: Small cell carcinoma (SCC) occurs mostly in the lung, and small cell lung cancer accounts for 13% of newly diagnosed lung cancers. Only 2.5% of SCC occurs in extrapulmonary sites, and SCC of pleural origin is especially very uncommon. Patient concerns: An 85-year-old man presenting with progressive dyspnea for more than 7 days. Diagnoses: Computed tomography scan of the chest showed massive pleural effusion and diffuse nodular thickening of the pleura on the right chest. Sonography-guided needle biopsy of the pleural mass was performed and histologic and immunohistochemical findings revealed SCC. Since n...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
Conclusions: 3D semiautomatic quantification of PPV is feasible and reproducible using CT in patients with occupational exposure to asbestos. PPV measurement may be useful to correlate with other asbestos-related disease outcomes and prognosis.
Source: Journal of Thoracic Imaging - Category: Radiology Tags: Original Articles Source Type: research
Specially trained beagles could one day detect mesothelioma by scent, according to the lead researcher of a recent study detailing the dog breed’s stunning accuracy with lung cancer. Dr. Thomas Quinn, clinical professor at the Lake Erie College of Osteopathic Medicine, believes the dogs could be equally effective with pleural mesothelioma, a rare cancer caused by asbestos exposure. “Absolutely, this could work with mesothelioma. There is no reason why it wouldn’t,” Quinn told The Mesothelioma Center at Asbestos.com. “That is another cancer with strong potential for this to work well.” Th...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news
1332Objectives: To investigate the value of 18F-FDG PET/CT imaging in differentiating malignant from benign exudative pleural effusions. Methods: 224 patients with CT scan and pleural effusion puncture examination evidence of moderate or massive exudative pleural effusions entered the study to evaluate the accuracy of 18F-FDG PET/CT in differential diagnosis between malignant and benign exudative pleural effusions. Image analysis of PET/CT was performed both with visual interpretation and using a quantitative method on coronal, sagittal and axial reconstructions. The results of PET/CT imaging were compared to cyto- or hist...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Lung Cancer Posters Source Type: research
Researchers at Osaka University in Japan have identified a key component of physical health associated with response to immunotherapy drugs. Among people with non-small cell lung cancer, higher levels of muscle mass predicted a better response to PD-1 inhibitor immunotherapy. Sarcopenia — the term used to describe low muscle mass levels — appears to reduce the benefits a person receives from immunotherapy cancer treatment. “Sarcopenia at baseline is a significant predictor of worse outcome in patients with advanced NSCLC [non-small cell lung cancer] receiving PD-1 blockade,” the study investigators ...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news
Lymphangitic carcinomatosis (LC) is a pattern of metastasis where tumor spreads along the pulmonary parenchymal lymphatics which produces a characteristic pattern of interlobular septa and axial peribronchial thickening. This pattern of metastatic disease is most typically associated with advanced disease and is observed in a range of malignancies including breast, lung, colon, and genitourinary origin. The presence of LC is usually associated with a poor prognosis and is readily detectable by computed tomography (CT) (1).
Source: Lung Cancer - Category: Cancer & Oncology Authors: Source Type: research
Doctors in China may have uncovered an effective second- or third-line treatment option for patients with malignant pleural mesothelioma. Dr. RongQin Meng, an oncologist at 363 Hospital in Cheng Du, said the investigational drug Apatinib (rivoceranib) could become part of a much-needed advance in mesothelioma treatment. After first- and second-line chemotherapy combinations had failed to slow tumor growth in a 58-year-old woman, Apatinib provided a five-month progression-free survival. “I was surprised at the result,” Meng told The Mesothelioma Center at Asbestos.com. “After taking the drug, the quality o...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news
We report a second primary lung cancer developing after pleurectomy/decortication for MPM. A 59-year-old man was diagnosed with MPM on the right side and underwent pleurectomy/decortication. Follow-up computed tomography detected a nodule in the right upper lobe that was diagnosed as adenocarcinoma by wedge resection. Lung cancer and MPM are associated with asbestos exposure. However, predicting lung cancer after treatment for MPM is difficult. Careful follow-up of the spared lung is necessary for detecting second primary lung cancer or MPM recurrence. PMID: 30558734 [PubMed - in process]
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: Ann Thorac Surg Source Type: research
We report a second primary lung cancer developing after pleurectomy/decortication for MPM. A 59-year-old man was diagnosed with MPM on the right side and underwent pleurectomy/decortication. Follow-up computed tomography detected a nodule in the right upper lobe that was diagnosed as adenocarcinoma by wedge resection. Lung cancer and MPM are associated with asbestos exposure. However, predicting lung cancer after treatment for MPM is difficult. Careful follow-up of the spared lung is necessary for detecting second primary lung cancer or MPM recurrence.
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
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