Respiratory Complications in Children with Prader Willi Syndrome

Prader Willi syndrome, resulting from the partial deletion or  lack of expression of a region of genes on the paternal chromosome 15, has a number of phenotypic features which predispose affected patients to ventilatory problems. These include generalised hypotonia, abnormal arousal and ventilatory responses to hypoxia and hypercapnia, scoliosis and fre quently, obesity. The spectrum of the resulting respiratory complications thus runs from sleep disordered breathing, to aspiration and respiratory functional impairment.
Source: Paediatric Respiratory Reviews - Category: Respiratory Medicine Authors: Tags: Review Source Type: research

Related Links:

Publication date: Available online 15 October 2019Source: International Review of NeurobiologyAuthor(s): Douglas B. Matthews, Amelia Schneider, Abigail Kastner, Samantha Scaletty, Rachel SzenayAbstractThe population of most countries is increasing and the United Nations predicts that by the year 2050 those over the age of 60 years old will increase from 900 million individuals to approximately 2.1 billion individuals (United Nations, 2015). The increase in the number of older individuals will place a strain on many national health care systems making it important to investigate behaviors in the aged that may negatively imp...
Source: International Review of Neurobiology - Category: Neuroscience Source Type: research
Publication date: January 2020Source: LWT, Volume 118Author(s): Vítor Spínola, Eulogio J. Llorent-Martínez, Paula C. CastilhoAbstractIn this work, we report the in vitro inhibitory potential of Rumex maderensis methanolic extracts (leaves, flowers, and stems) towards key digestive enzymes linked to type-2 diabetes and obesity (α-amylase, α-glucosidase, pancreatic lipase). The inhibitory activity towards aldose reductase and glycation of bovine serum albumin (BSA) is also reported; in these latter assays, the effect of simulated digestion on the bioactivities was evaluated. The inhibitory ac...
Source: LWT Food Science and Technology - Category: Food Science Source Type: research
Publication date: Available online 15 October 2019Source: Physiology &BehaviorAuthor(s): Konstantin V. Danilenko, Eugenii Kobelev, Ekaterina A. Semenova, Lyubomir I. AftanasABSTRACTThe study aimed to quantify a seasonal change in circadian rhythms and its relationship to the social/sleep regimen in humans living in Novosibirsk (55°N), using the naturalistic situation that daylight saving time transitions have been abolished in Russia. Sixty-three volunteers entered the study, and 46 completed it. One group got up at ∼6am and another at ∼7am during their regular 5-workdays schedule. They collected 19 saliva ...
Source: Physiology and Behavior - Category: Physiology Source Type: research
This study was to investigate the degree of susceptibility to intermittent hypoxia (IH), a hallmark of obstructive sleep apnea (OSA), between the two mice inbred lines C57BL/6N (6N) and C57BL/6J (6J).Materials and methodsFour-week old male mice of 6N and 6J substrains (n = 8) were randomized to standard diet (SD) group or high fat (HF) diet group. At the age of 13-week, all two groups of mice were subjected to either air or IH (IH30; thirty hypoxic events per hour) for one week.Key findingsAll mice fed with HF diet exhibited obesity with more body weight and fat mass (percentage to body weight) gain. IH reduced serum L...
Source: Life Sciences - Category: Biology Source Type: research
In this study, a Bayesian classifier with the multivariate distribution based on the D-vine copula model is developed and evaluated for the awake/drowsiness interpretation during the power nap. The objective is to consider the correlation among the features into the automatic classification algorithm. A power nap is a short sleep process, which is commonly considered as a supplement to the insufficient overnight sleep. It may involve the states of awake and drowsiness. Neurophysiological features are extracted from the EEGs (electroencephalography) and EOGs (electrooculography), which are synchronously recorded during one'...
Source: Biomedical Signal Processing and Control - Category: Biomedical Science Source Type: research
Publication date: Available online 16 October 2019Source: Respiratory InvestigationAuthor(s): Satoshi Hokari, Toshiaki KikuchiAbstractPostoperative pulmonary complications (PPCs) are considered as a leading cause of poor surgical outcomes, and occur frequently even in non-cardiothoracic surgery. Several multifactorial risk indices show potential effectiveness in identification of patients at high risk of developing PPCs. In preoperative consultation from surgeons, pulmonologists often act as gatekeepers for indication of surgery. With regard to preventive strategy for PPCs, recent reports have suggested the usefulness of p...
Source: Respiratory Investigation - Category: Respiratory Medicine Source Type: research
In conclusion, adult weight gain was associated with increased risk of several major cancers. The degree, timing, and duration of overweight and obesity also seemed to be important. Preventing weight gain may reduce the cancer risk. Link:
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
Credit: Busani Bafana/IPSBy Esther Ngumbi and Ifeanyi NsoforILLINOIS, United States / ABUJA, Oct 16 2019 (IPS) United Nations World Food Day is celebrated around the world on October 16 under the theme: “Our Actions ARE Our Future. Healthy Diets for a Zero Hunger World”. This theme is timely, especially, because across Africa and around the world, there has been a gradual rise in malnutrition and diet-related non communicable diseases, as highlighted in The Lancet study and a United Nations Report published earlier this year. While 45 percent of deaths in children are from nu...
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Food & Agriculture Global Headlines Health World Food Day Source Type: news
Do obese individuals with NAFLD who are"metabolically healthy" (i.e., without diabetes, hypertension or high lipid levels) differ in fibrosis progression versus those with these risk factors?Liver International
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news
Conclusions: If the general pediatrician bec omes more familiar with PWS, the diagnosis and treatment will start earlier, which is essential to improve the quality of life and care for these individuals.
Source: Revista Paulista de Pediatria - Category: Pediatrics Source Type: research
More News: Back Curves | Children | Eating Disorders & Weight Management | Genetics | Obesity | Pediatrics | Prader-Willi Syndrome | Respiratory Medicine | Scoliosis | Sleep Disorders | Sleep Medicine