Respiratory Complications in Children with Prader Willi Syndrome

Prader Willi syndrome, resulting from the partial deletion or  lack of expression of a region of genes on the paternal chromosome 15, has a number of phenotypic features which predispose affected patients to ventilatory problems. These include generalised hypotonia, abnormal arousal and ventilatory responses to hypoxia and hypercapnia, scoliosis and fre quently, obesity. The spectrum of the resulting respiratory complications thus runs from sleep disordered breathing, to aspiration and respiratory functional impairment.

Source: Paediatric Respiratory Reviews - August 9, 2016 Category: Respiratory Medicine Authors: H-L Tan, D.S. Urquhart Tags: Review Source Type: research