Prognostic Significance of The Cereblon Expression in Multiple Myeloma Patients

Within a personalized treatment approach in multiple myeloma (MM), prognostic significance of the cereblon (CRBN) expression was analysed in 92 newly diagnosed patients. In patients treated with thalidomide based combinations, CRBN expression significantly affected treatment response (p=0.028), and progression free survival (PFS, p=0.017). Implicating treatment outcome, the level of CRBN expression may represent additional prognostic tool in personalized treatment approach.

Source: Clinical Lymphoma, Myeloma and Leukemia - August 9, 2016 Category: Hematology Authors: Jelena Bila, Aleksandra Sretenovic, Jelena Jelicic, Natasa Tosic, Irena Glumac, Marija Dencic Fekete, Darko Antic, Milena Todorovic Balint, Olivera Markovic, Zoran Milojevic, Milica Radojkovic, Goran Trajkovic, Mila Puric, Sonja Pavlovic, Biljana Mihaljev Tags: Original Study Source Type: research