Key Molecular Drivers of Chronic Lymphocytic Leukaemia (CLL)

Chronic lymphocytic leukaemia (CLL) is an adult neoplastic disease of B-cells that is characterised by variable clinical outcomes. While some patients have an aggressive form of the disease and often encounter treatment failure and short survival, others have more stable disease with long-term survival and little or no need for treatment. In the last decade, significant advances have been made in our understanding of the molecular drivers that impact on the natural pathology of CLL. This review describes what is known about these key molecules in the context of their role in tumour pathogenicity, prognosis and therapy.
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Tags: Review Article Source Type: research