Single-Center Series of Bone-Marrow Biopsy-Defined Large Granular Lymphocyte leukemia; high rates of sustained response to oral methotrexate

39 patients were stringently diagnosed with large granular lymphocyte leukemia. 15 (38%) remain untreated, 13/24 initially treated with prednisolone, overall response rate (ORR) 84.6%, median duration of response (DOR) 13.5 months, 9/24 received oral methotrexate ORR 89%, median DOR 132.7 months. Five received methotrexate following prednisolone failure; all responded. Single agent oral methotrexate results in long responses with minimal toxicity.

Source: Clinical Lymphoma, Myeloma and Leukemia - August 9, 2016 Category: Hematology Authors: Talha Munir, Mark J. Bishton, Ian Carter, Andrew McMillan, Simon O ’Connor, Vishakha Sovani, Andrew P. Haynes, Christopher P. Fox Tags: Original Study Source Type: research