New metabolites produced by Fusarium solani T-13 isolated from a dead branch

Publication date: September 2016 Source:Phytochemistry Letters, Volume 17 Author(s): Yoshihito Shiono, Nanang Rudianto Ariefta, Chairil Anwar, Sabirin Matsjeh, Ruengrit Sappapan, Tetsuya Murayama, Takuya Koseki, Tetsuaki Kawamura, Shota Uesugi, Ken-ichi Kimura Three novel benzenediol lactone derivatives, 7-hydroxy-14-de-O-methyl-lasiodiplodin (2), ethyl-3,5-dihydroxy-7-(6,8-dihydroxynonyl)benzoate (4), and 7-ethylbenzoate-7-heptanoic acid (5), together with known compounds, 14-de-O-methyl-lasiodiplodin (1) and ethyl-3,5-dihydroxy-7-(8-hydroxynonyl)benzoate (3), were isolated from the culture of Fusarium solani T-13, a fungus from a dead branch. Their structures were elucidated using 1D- and 2D-NMR spectroscopy. Compounds 1, 3 and 4 showed doughnut like phenotypes of growth restoring activity against the mutant yeast (zds1Δ erg3Δ pdr1/3Δ) at the concentration of 0.16, 0.63 and 1.25μg/spot, respectively. Graphical abstract

Source: Phytochemistry Letters - August 9, 2016 Category: Chemistry Source Type: research