Canonical Wnt/ β-Catenin Signaling Pathway Is Dysregulated in Patients With Primary and Secondary Myelofibrosis

Activation of the canonical wingless-related integration site (Wnt)/ β-catenin signaling pathway is associated with malignant transformation, development of fibrosis, and angiogenesis. We analyzed β-catenin mRNA expression in bone marrow of 29 patients with primary (PMF), 4 with secondary (SMF) myelofibrosis, and 16 control participants using quantitative real-time polymerase chain reaction (qRT PCR). β-Catenin expression is increased in PMF and SMF and might potentiate anemia.

Source: Clinical Lymphoma, Myeloma and Leukemia - June 7, 2016 Category: Hematology Authors: Marko Lucijanic, Ana Livun, Cedna Tomasovic-Loncaric, Tajana Stoos-Veic, Vlatko Pejsa, Ozren Jaksic, Zeljko Prka, Rajko Kusec Tags: Original Study Source Type: research