Anaplastic Multiple Myeloma: An Aggressive Variant With a Poor Response to Novel Therapies

Anaplastic multiple myeloma (AMM) is a very rare and aggressive morphologic variant of multiple myeloma with a historically poor prognosis.1 The term “anaplastic myeloma” is used to describe a plasma cell malignancy involving immature plasma cells of pleomorphic morphology with high-grade transformation and extramedullary involvement with large, poorly differentiated cells.1-3 Anaplastic morphology can be present at the initial diagnosis or c an appear later in the disease course.4-6 Historically, this disease has been very resistant to chemotherapy.

Source: Clinical Lymphoma, Myeloma and Leukemia - June 7, 2016 Category: Hematology Authors: Nischala Ammannagari, Kimberly Celotto, Vishala Neppalli, Kelvin Lee, Sarah A. Holstein Tags: Case Report Source Type: research