Neuroendocrine tumours of the gynecological tract

Purpose of review: The purpose of this article will be to review neuroendocrine tumours (NETs) of the gynaecological tract. NETs are generally considered to be uncommon and primary tumours in the gynaecological tract on arrival rare or very rare. It is important to distinguish true primary tumours from metastatic as the management is very different. These tumours ranged from highly aggressive small cell carcinomas (SCCs) sometimes associated with secretion of neuropeptides that may be functional and cause distinctive syndromes. On the other hand, the well differentiated low-grade NETs generally behave in a very indolent manner with an excellent prognosis. Very recent new data have identified a molecular marker for small cell carcinomas of the ovary although as yet there is no associated candidate drug. Recent findings: Recent developments include the identification of a molecular marker for small cell carcinomas of the ovary of hypercalcaemic type; this will help to identify these tumours more confidently. New therapeutic developments for well differentiated NETs include mammalian target of rapamycin pathway inhibitors and peptide receptor radionuclide therapy. Summary: In summary, these are rare tumours with a low incidence although higher prevalence. They require a multidisciplinary approach to management and should be supervised by specialist teams familiar with NETs.
Source: Current Opinion in Oncology - Category: Cancer & Oncology Tags: GYNECOLOGIC CANCER: Edited by Martin Gore Source Type: research

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Source: Genetics and Molecular Biology - Category: Genetics & Stem Cells Source Type: research
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Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
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Source: - Category: Research Source Type: clinical trials
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Source: - Category: Research Source Type: clinical trials
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Source: - Category: Research Source Type: clinical trials
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Publication date: Available online 14 November 2019Source: Seminars in Cancer BiologyAuthor(s): Tibor Tot, Maria Gere, Syster Hofmeyer, Annette Bauer, Ulrika PellasAbstractMany breast lesions are associated with microcalcifications that are detectable by mammography. In most cases, radiologists are able to distinguish calcifications usually associated with benign diseases from those associated with malignancy. In addition to their value in the early detection of breast carcinoma and accurate radiological diagnosis, the presence of microcalcifications often affects the extent of surgical intervention. Certain types of micro...
Source: Seminars in Cancer Biology - Category: Cancer & Oncology Source Type: research
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Source: Journal of the American Society of Cytopathology - Category: Cytology Source Type: research
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Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
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Source: Reports of Practical Oncology and Radiotherapy - Category: Cancer & Oncology Source Type: research
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