Diagnostic work-up of pulmonary nodules : Management of pulmonary nodules detected with low ‑dose CT screening.

[Diagnostic work-up of pulmonary nodules : Management of pulmonary nodules detected with low‑dose CT screening]. Radiologe. 2016 Aug 5; Authors: Wormanns D Abstract Pulmonary nodules are the most frequent pathological finding in low-dose computed tomography (CT) scanning for early detection of lung cancer. Early stages of lung cancer are often manifested as pulmonary nodules; however, the very commonly occurring small nodules are predominantly benign. These benign nodules are responsible for the high percentage of false positive test results in screening studies. Appropriate diagnostic algorithms are necessary to reduce false positive screening results and to improve the specificity of lung cancer screening. Such algorithms are based on some of the basic principles comprehensively described in this article. Firstly, the diameter of nodules allows a differentiation between large (>8 mm) probably malignant and small (
Source: Der Radiologe - Category: Radiology Authors: Tags: Radiologe Source Type: research

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Researchers are using artificial intelligence to measure a common marker of heart disease via lung cancer screenings. The research was presented at the annual meeting of the Radiological Society of North America (RSNA). Low-dose chest CT is approved for lung cancer screening in high-risk people, such as long-time smokers. While these CT scans are intended to diagnose lung cancer, coronary artery calcium, a measure of plaque in the arteries, is also visible on CT. The coronary artery calcium score derived from CT is a well-established measure that helps doctors decide who should get cholesterol-lowering preventive medicatio...
Source: MDDI - Category: Medical Devices Authors: Tags: Digital Health IVD Source Type: news
ConclusionsIn an experienced MTB, the agreement between imaging specialists and the rest of the MTB with regard to the interpretation of images is high in a setting of posttreatment lung cancer image surveillance. It seems that in cases of disagreements, the rates of more accurate interpretation are well balanced between imaging specialists and the MTB.Trial registrationISRCTN16281786, Date 23. February 2017.
Source: Multidisciplinary Respiratory Medicine - Category: Respiratory Medicine Source Type: research
3D FULLY CONVOLUTIONAL NETWORKS FOR CO-SEGMENTATION OF TUMORS ON PET-CT IMAGES. Proc IEEE Int Symp Biomed Imaging. 2018 Apr;2018:228-231 Authors: Zhong Z, Kim Y, Zhou L, Plichta K, Allen B, Buatti J, Wu X Abstract Positron emission tomography and computed tomography (PET-CT) dual-modality imaging provides critical diagnostic information in modern cancer diagnosis and therapy. Automated accurate tumor delineation is essentially important in computer-assisted tumor reading and interpretation based on PET-CT. In this paper, we propose a novel approach for the segmentation of lung tumors that combines the ...
Source: Proceedings - International Symposium on Biomedical Imaging - Category: Radiology Tags: Proc IEEE Int Symp Biomed Imaging Source Type: research
AbstractOur knowledge about the incidence of pulmonary embolism (PE) and the performance of age adjusted D-dimers (Dd) cutoff amongst patients with lung cancer (LC) and suspected PE, remains limited. We retrospectively analyzed all clinically suspected patients who underwent computed tomography pulmonary angiography (CTPA) in a tertiary hospital during a 19  month period. Cancer diagnosis was established using ICD10 code. Eligible for Dd analysis were those tested up to 24 h prior to the scan. We analyzed 2549 patients (54.6% males, median age 68.8 years, IQR 57–78), 15.8% had active LC and 5.4% other ...
Source: Journal of Thrombosis and Thrombolysis - Category: Hematology Source Type: research
Publication date: Available online 29 November 2019Source: Academic RadiologyAuthor(s): Yi Liu, Yanhua Tang, Zhiqiang Xue, Xin Jin, Guangyu Ma, Po Zhao, Xiangyang ChuPurposeTo investigate the features of 18F-Fluoro-D-glucose positron emission tomography/computed tomography (18F-FDG PET/CT) in differentiating synchronous multiple primary lung cancers (sMPLC) from intropulmonary metastasis (IM).Material and MethodsFifty-nine patients with two synchronous primary lung cancers were selected and 23 lung cancer patients with an additional solitary IM cancer were chosen as the control group between January 2009 and January 2019. ...
Source: Academic Radiology - Category: Radiology Source Type: research
The objective of the present study was to evaluate the prognostic value of low trunk muscle mass in predicting overall survival in these patients.MethodsThe data from 198 patients who were diagnosed with bone metastases from lung cancer from April 2009 to May 2017 were retrospectively reviewed. The areas of the psoas and paravertebral muscles were measured at the level of the third lumbar vertebra on computed tomography scans taken at the time nearest to the diagnosis of bone metastasis. Muscle area was evaluated for male and female cohorts separately using different cutoff points. Cox proportional hazards analysis was per...
Source: Supportive Care in Cancer - Category: Cancer & Oncology Source Type: research
ConclusionsThe SUVmax of contralateral interstitial lesions in18F-FDG PET/CT images might be useful for predicting the onset of AE-ILD in patients with lung cancer and ILD treated with chemotherapy.
Source: International Journal of Clinical Oncology - Category: Cancer & Oncology Source Type: research
There are limited data on the clinical efficiency of afatinib in non ‐small cell lung cancer (NSCLC) patients with uncommon epidermal growth factor receptor (EGFR) mutations. Moreover, the efficacy and safety of afatinib in elderly patients with these mutations has not been established. Here, we describe a case of successful treatment of a patient aged>80  years with lung adenocarcinoma positive for the uncommon EGFR L861Q mutation with low‐dose afatinib. An 83‐year‐old woman presented with cough and dyspnea. A chest computed tomography (CT) scan revealed tumors in the left upper lobe, left pleural effusi...
Source: Thoracic Cancer - Category: Cancer & Oncology Authors: Tags: CASE REPORT Source Type: research
IMPROVING TUMOR CO-SEGMENTATION ON PET-CT IMAGES WITH 3D CO-MATTING. Proc IEEE Int Symp Biomed Imaging. 2018 Apr;2018:224-227 Authors: Zhong Z, Kim Y, Zhou L, Plichta K, Allen B, Buatti J, Wu X Abstract Positron emission tomography and computed tomography (PET-CT) plays a critically important role in modern cancer therapy. In this paper, we focus on automated tumor delineation on PET-CT image pairs. Inspired by co-segmentation model, we develop a novel 3D image co-matting technique making use of the inner-modality information of PET and CT for matting. The obtained co-matting results are then incorpora...
Source: Proceedings - International Symposium on Biomedical Imaging - Category: Radiology Tags: Proc IEEE Int Symp Biomed Imaging Source Type: research
AbstractWhile molecular imaging with positron emission tomography or single-photon emission computed tomography already reports on tumour molecular mechanisms on a macroscopic scale, there is increasing evidence that there are multiple additional features within medical images that can further improve tumour characterization, treatment prediction and prognostication. Early reports have already revealed the power of radiomics to personalize and improve patient management and outcomes. What remains unclear is how these additional metrics relate to underlying molecular mechanisms of disease. Furthermore, the ability to deal w...
Source: European Journal of Nuclear Medicine and Molecular Imaging - Category: Nuclear Medicine Source Type: research
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