Capacit é de la biopsie de la prostate à prédire le score réel du cancer de la prostate?

Conclusion Le score de Gleason ne reflète qu’imparfaitement celui de la pièce opératoire, ainsi ces limites de stadification doivent être bien comprises lors de la détermination des stratégies thérapeutiques. Objective To evaluate the correlation between Gleason score at needle biopsy and prostatectomy specimen. Subjects and Methods We reviewed the records of 47 patients treated for prostate cancer by radical prostatectomy and the evaluation of the agreement was made according to the differentiation groups (well, moderately and poorly differentiated). Results The concordance of the Gleason score was 70%, a sub-staging of 25.5%, and 4.2% for on-staging. For the positive predictive value (PPV), well differentiated group was 81.25% and 100% for moderately differentiated group. The Kappa concordance coefficient was 0.36 with a better concordance observed in the moderately differentiated group. Conclusion The biopsy Gleason score imperfectly reflects the one of radical prostatectomy specimens. However, these limits of staging must be understood in the determination of therapeutic strategies.
Source: African Journal of Urology - Category: Urology & Nephrology Source Type: research