Correlation of Apparent Diffusion Coefficient to cognitive impairment in Relapsing remittent multiple sclerosis (plaque, peri-plaque and Normal appearing white matter)

Conclusions ADC values in peri-plaque and NAWM have an inverse correlation with cognition in MS. The ADC is useful for detecting subtle abnormalities in white matter and can be used as a predictor of cognitive state.
Source: The Egyptian Journal of Radiology and Nuclear Medicine - Category: Nuclear Medicine Source Type: research

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Publication date: Available online 22 February 2020Source: Multiple Sclerosis and Related DisordersAuthor(s): Chi Hou, Wenlin Wu, Yang Tian, Yani Zhang, Haixia Zhu, Yiru Zeng, Bingwei Peng, Kelu Zheng, Xiaojing Li, Wenxiong ChenAbstractObjective: To analyze the clinical features in children with anti-NMDAR encephalitis combined with myelin oligodendrocyte glycoprotein antibody (MOG ab).Methods: Clinical data of 7 children with anti-NMDAR encephalitis combined with MOG ab(+) were collected in Guangzhou Women and Children's Medical Center from January, 2016 to June, 2019. Children with NMDAR ab(+)/MOG ab(-) and MOG ab(+)/NMD...
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
ConclusionIn our study EDI symptoms could not be objectified since EDI and non-EDI groups did not differ in terms of change in mood, cognition and fatigue between day 0 and 7 suggesting that symptom recrudescence could be a subjective experience. Although our results need to be interpreted cautiously, we found no clear correlation between studied serum cytokines concentrations and the occurrence of EDI symptoms.
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Publication date: Available online 22 February 2020Source: Multiple Sclerosis and Related DisordersAuthor(s): J. Rigal, J. Ciron, Z. Lépine, D. BiottiAbstractFew cases of late onset neutropenia after RITUXIMAB treatment (LONART) have been reported in patients with neuroinflammatory disorders. We conducted a retrospective analysis of patients treated with RITUXIMAB for neuromyelitis optica spectrum disorders (NMOSD), MOG-antibody-associated disease (MOGAD) and multiple sclerosis (MS) at the Toulouse University Hospital from November 2007 to October 2019.Ten patients with LONART were identified in a total of 385 patie...
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Publication date: Available online 22 February 2020Source: Multiple Sclerosis and Related DisordersAuthor(s): Alessio Amedoro, Anna Berardi, Antonella Conte, Elisa Pelosin, Donatella Valente, Giuseppe Maggi, Marco Tofani, Giovanni GaleotoAbstractBackgroundThe aquatic environment has unique properties, such a buoyancy, turbulence, hydrostatic pressure, and resistance, which can be used to gain a range of exercise benefits. During the last decade, hydrotherapy has spread in a very heterogeneous rehabilitation field. However, the efficacy of this kind of rehabilitation is not clear in scientific literature. The purpose of thi...
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
ConclusionTesting for MOG Abs should be considered in children with isolated and unexplained seizures, and in adults with suspected encephalitis and/or seizures. In these cases, MOG Abs detection is highly relevant for patients’ clinical management.
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Publication date: Available online 22 February 2020Source: Multiple Sclerosis and Related DisordersAuthor(s): Mohammad Hossein Harirchian, Maryam Poursadeghfard, Alireza Sadeghipour, Hoda Kamali, Payam SarrafAbstractFingolimod has been the first approved oral medication in MS for its relapsing remitting type. It is a non-selective sphingosine1-phosphate (S1P) receptor modulator on lymphocytes. Engagement of this receptor blocks the T cells and B cells migration from the lymph nodes into the inflamed central nervous system (CNS) via bloodstream. In spite of this known immunomodulatory mechanism, there are some reports about...
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Abstract Multiple sclerosis (MS) is a chronic inflammatory and demyelinating disease of the central nervous system. The disease affects more women than men and often is diagnosed during a woman's childbearing years. Typical clinical presentations of the disease are extensive and variable, with symptoms that include dysregulated mood, fatigue, vision problems, weakness, tremor, imbalance, abnormal sensations, bladder dysfunction, and heat sensitivity. If a woman aged 15-50 years experiences these neurologic symptoms in isolation or combination, and the symptoms are not explained by other underlying medical conditio...
Source: Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Obstet Gynecol Source Type: research
Publication date: Available online 22 February 2020Source: SteroidsAuthor(s): Asadollah Mohammadi, Asaad Azarnezhad, Hashem Khanbabaei, Esmael Izadpanah, Rasoul Abdollahzadeh, George E. Barreto, Amirhossein SahebkarAbstractThere are conflicting results regarding the exact effect of the vitamin D receptor (VDR) gene polymorphisms on the susceptibility to multiple sclerosis (MS). Therefore, we aimed to investigate the impact of four major studied VDR gene polymorphisms consisting of ApaI, BsmI, FokI, and TaqI on the risk of MS in the Iranian population. A literature search was performed in various databases to find case-cont...
Source: Steroids - Category: Drugs & Pharmacology Source Type: research
Medicinal cannabinoid use continues to evolve across the United States, although legitimate federal recognition for medicinal purpose is lacking. Variability exists across states within the United States with respect to legislation, and health care institutions encounter challenges when patients present with a history of medicinal cannabinoid use. Emerging evidence in the field of neurosciences suggests a role of cannabinoids for neurologic medical conditions such as Parkinson disease, multiple sclerosis, and epilepsy. We aim to provide an overview of cannabinoids including a historical perspective, pharmacology, applicati...
Source: Critical Care Nursing Quarterly - Category: Nursing Tags: Original Articles Source Type: research
We report the first two patients, who underwent in vitro maturation protocol in order to avoid the exacerbation risk due to controlled ovarian stimulation at a large tertiary university hospital. Both patients were referred to our infertility clinic with the concern of multiple sclerosis exacerbation after or during controlled ovarian stimulation treatment. The patients underwent in vitro maturation protocol in order to avoid ovarian stimulating agents. Both patients gave birth to healthy babies at term. They did not suffer any multiple sclerosis relapses during their treatment and during pregnancy. Controlled ovarian stim...
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research
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